期刊
CLINICAL CHEMISTRY
卷 68, 期 4, 页码 511-520出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/clinchem/hvab278
关键词
creatinine; cystatin C; eGFR; estimated glomerular filtration rate; chronic kidney disease
Recognizing that race is a social construct, there is a push to remove race from clinical algorithms for diagnosing kidney diseases. The Task Force recommends using the newly published CKD-EPI 2021 equation for eGFR calculations without a race coefficient.
Recognizing that race is a social and not a biological construct, healthcare professionals and the public have called for removal of race in clinical algorithms. In response, the National Kidney Foundation and the American Society of Nephrology created the Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Diseases to examine the issue and provide recommendations. The final report from the Task Force recommends calculating estimated glomerular filtration rate (eGFR) without a race coefficient using the recently published CKD-EPI 2021 creatinine (cr) and creatinine-cystatin C (cr-cys) equations. The Task Force recommends immediately replacing older eGFR(cr) equations (MDRD Study and CKD-EPI 2009) with the new CKD-EPI 2021 equation. In a 2019 survey by the College of American Pathologists, 23% of 6200 laboratories reporting eGFR(cr) used an incorrect equation that is not suitable for use with standardized creatinine measurements, 34% used the CKD-EPI 2009 equation and 43% used the MDRD Study 2006 equation re-expressed for standardized creatinine measurement. Rapid transition to using the CKD-EPI 2021 equation is an opportunity for laboratories to standardize to a single equation to eliminate differences in eGFR(cr) due to different equations used by different laboratories, and to report eGFR without use of race. We provide guidance to laboratories for implementing the CKD-EPI 2021 equations for both eGFR(cr) and eGFR(cr-cys).
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