期刊
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
卷 49, 期 2, 页码 319-326出版社
WILEY
DOI: 10.1111/1440-1681.13602
关键词
formalin; Fos-like immunoreactivity; inflammatory factors; L-Serine-O-phosphate; nociceptive behaviours
资金
- National Natural Science Foundation of China [31000481]
- Shanxi Scholarship Council of China [HGKY2019054]
- Natural Science Foundation of Shanxi Province, China [201801D121316, 2011011040-2]
- Key Laboratory of Cellular Physiology (Shanxi Medical University), Ministry of Education, China [KLMEC/SXMU-202010]
- Shanxi '1331 Project' Key Subjects Construction (1331KSC)
This study investigated the role of peripheral group III metabotropic glutamate receptors in formalin-evoked nociception, showing that agonists of these receptors can reduce pain by inhibiting pro-inflammatory cytokines in the spinal cord.
Intraplantar injection of formalin produces persistent spontaneous nociception and hyperalgesia. The underlying mechanism, however, remains unclear. The present study was, therefore, designed to determine the roles of peripheral group III metabotropic glutamate receptors (mGluRs) in formalin-evoked spontaneous nociception. Pre-treatment with intraplantar injections of L-serine-O-phosphate (L-SOP), a group III mGluRs agonist, significantly inhibited formalin-induced nociceptive behaviours and decreased Fos production in the spinal dorsal horn. The inhibitory effects of L-SOP were abolished completely by pre-treatment with the group III mGluR antagonist (RS)-a-methylserine-O-phosphate (M-SOP). These data suggest that the activation of group III mGluRs in the periphery may play a differential role in formalin-induced nociception. In addition, L-SOP decreased the formalin-induced upregulation of tumour necrosis factor-alpha (TNF-alpha) as well as interleukine-1 beta (IL-1 beta) expression in the spinal cord, suggesting that activation of peripheral group III mGluRs reduces formalin-induced nociception through inhibition of the pro-inflammatory cytokines in the spinal cord. Therefore, the agonists acting peripheral group III mGluRs possess therapeutic effectiveness in chronic pain.
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