期刊
CLINICAL AND EXPERIMENTAL NEPHROLOGY
卷 26, 期 5, 页码 415-423出版社
SPRINGER
DOI: 10.1007/s10157-021-02169-7
关键词
Solitary kidney; Cardiovascular risk; Children; Carotid intima-media thickness; Ischemia-modified albumin; 24-h ambulatory blood pressure monitoring
This study found that patients with a solitary kidney are at a higher risk of developing cardiovascular disease, as their kidney function and blood pressure are abnormal. Therefore, close monitoring of these patients should be conducted to prevent severe kidney impairment.
Background The present study investigates cardiovascular risk and kidney damage in patients with solitary kidneys. Methods Included in the study were 40 children with a unilateral functioning kidney and 60 healthy controls, all of whom were evaluated for carotid intima-media thickness, ischemia-modified albumin and oxidative stress parameters, and 24-h ambulatory blood pressure monitoring. Results Serum creatinine and urine microalbumin levels were higher and creatinine clearance was lower in the patient group than in the control group, and serum ischemia-modified albumin, carotid intima-media thickness, aldosterone, plasma renin activity and blood pressure were all higher in the patient group than in the control group. In addition, the patient group was showed a non-dipper pattern. Conclusion Children with a normal functioning solitary kidney are likely at higher risk of developing cardiovascular disease and such patients should be followed closely before marked kidney impairment occurs.
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