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Big data and reference intervals

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Article Medical Laboratory Technology

Indirect reference intervals for haematological parameters in capillary blood of pre-school children

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Summary: The indirect method used in this study successfully calculated reference intervals for various hematological parameters in preschool children. Gender differences in reference intervals indicate the need for intra-laboratory determination of reference intervals based on specific populations and sample types.

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Verifying Clinically Derived Reference Intervals for Daily Excretion Rates of Fractionated Metanephrines Using Modern Indirect Reference Interval Models

Kelly Doyle et al.

Summary: The study explored the feasibility of using indirect methods to verify reference intervals for urinary metanephrine metabolites. Different decomposition models were found to be necessary for different demographic groups, and careful data transformation is essential for accurate analysis results. Overall, gamma mixture models showed good agreement without the need for data transformation.

AMERICAN JOURNAL OF CLINICAL PATHOLOGY (2021)

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Comparison of reference intervals derived by direct and indirect methods based on compatible datasets obtained in Turkey

Yesim Ozarda et al.

Summary: This study evaluated the accuracy of indirectly predicted reference intervals compared to those established directly, revealing significant biases. More rigorous data cleaning is necessary to reduce prediction biases.

CLINICA CHIMICA ACTA (2021)

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Age- and sex-related reference interval for free thyroxine: An indirect approach

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ANNALS OF CLINICAL BIOCHEMISTRY (2021)

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Effect of sample size and the traditional parametric, nonparametric, and robust methods on the establishment of reference intervals: Evidence from real world data

Chaochao Ma et al.

Summary: The study established reference intervals for thyroid-stimulating hormone (TSH) using different sample sizes and statistical methods, showing that the RIs established using the three methods were more consistent when sample size was greater than 2000.

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Reference intervals established using indirect method for serum ferritin assayed on Abbott Architect i2000SR analyzer in Chinese adults

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Retinol and α-tocopherol in pregnancy: Establishment of reference intervals and associations with CBC

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Real-world big-data studies in laboratory medicine: Current status, application, and future considerations

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TSH continuous reference intervals by indirect methods: A Comparisons to Partitioned Reference Intervals

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Albumin and calcium reference interval using healthy individuals and a data-mining approach

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Use of data mining in the establishment of age-adjusted reference intervals for parathyroid hormone

Jose Antonio Delgado et al.

CLINICA CHIMICA ACTA (2020)

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The Importance of Establishing Reference Intervals - is it still a Current Problem for Laboratory and Doctors?

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A multicenter study for the evaluation of the reference interval for TSH in Italy (ELAS TSH Italian Study)

Aldo Clerico et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2019)

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Mining the Age-Dependent Reference Intervals of B Vitamins from Routine Laboratory Test Results

Osman Evliyaoglu et al.

LABORATORY MEDICINE (2019)

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Mining the Age-Dependent Reference Intervals of B Vitamins from Routine Laboratory Test Results

Osman Evliyaoglu et al.

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Widespread Incorrect Implementation of the Hoffmann Method, the Correct Approach, and Modern Alternatives

Daniel T. Holmes et al.

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Reference interval by the indirect approach of serum thyrotropin (TSH) in a Mediterranean adult population and the association with age and gender

Bruna Lo Sasso et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2019)

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A new indirect estimation of reference intervals: truncated minimum chi-square (TMC) approach

Werner Wosniok et al.

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Reference intervals for gastrointestinal tumor markers (AFP, CEA, CA199 and CA724) in healthy adults of Han nationality in Chongqing by Roche ECLIA system

Hongsong Yu

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION (2019)

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Limitations of the Hoffmann method for establishing reference intervals using clinical laboratory data

Ying Zhang et al.

CLINICAL BIOCHEMISTRY (2019)

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Data mining of reference intervals for coagulation screening tests in adult patients

Jakob Zierk et al.

CLINICA CHIMICA ACTA (2019)

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Indirect method for validating transference of reference intervals

Simon Lykkeboe et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2018)

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Reference intervals for thyrotropin in an area of Northern Italy: the Pordenone thyroid study (TRIPP)

R. Tozzoli et al.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2018)

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Data mining: Seasonal and temperature fluctuations in thyroid-stimulating hormone

Danchen Wang et al.

CLINICAL BIOCHEMISTRY (2018)

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Parathyroid hormone: Data mining for age-related reference intervals in adults

Christopher-John L. Farrell et al.

CLINICAL ENDOCRINOLOGY (2018)

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Data mining for age-related TSH reference intervals in adulthood

Christopher-John L. Farrell et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2017)

Review Medical Laboratory Technology

Critical comments to a recent EFLM recommendation for the review of reference intervals

Rainer Haeckel et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2017)

Review Medical Laboratory Technology

Statistical methods used in the calculation of geriatric reference intervals: a systematic review

Erika Arseneau et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2016)

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An unsupervised learning method to identify reference intervals from a clinical database

Sarah Poole et al.

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Determination of reference range with the indirect method of the 25-hydroxyvitamin D3 test in the Balikesir region, Turkey

Medine Alpdemir et al.

TURKISH JOURNAL OF MEDICAL SCIENCES (2016)

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Reference Intervals for Intestinal Disaccharidase Activities Determined from a Non-Reference Population

Sarah A. Hackenmueller et al.

JOURNAL OF APPLIED LABORATORY MEDICINE (2016)

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Reference Intervals Data Mining No Longer a Probability Paper Method

Alexander Katayev et al.

AMERICAN JOURNAL OF CLINICAL PATHOLOGY (2015)

Article Medical Laboratory Technology

Age- and Sex-Specific Dynamics in 22 Hematologic and Biochemical Analytes from Birth to Adolescence

Jakob Zierk et al.

CLINICAL CHEMISTRY (2015)

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Effect of age and gender on reference intervals of red blood cell distribution width (RDW) and mean red cell volume (MCV)

Johannes J. M. L. Hoffmann et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2015)

Article Medical Laboratory Technology

Indirect Estimation of Reference Intervals for Thyroid Parameters

Neda Milinkovic et al.

CLINICAL LABORATORY (2014)

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Indirect determination of pediatric blood count reference intervals

Jakob Zierk et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2013)

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Establishing Reference Intervals for Clinical Laboratory Test Results Is There a Better Way?

Alex Katayev et al.

AMERICAN JOURNAL OF CLINICAL PATHOLOGY (2010)

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Indirect Reference Intervals Estimated from Hospitalized Population for Thyrotropin and Free Thyroxine

Tamer C. Inal et al.

CROATIAN MEDICAL JOURNAL (2010)

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Reproducibility of impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) classification: a systematic review

Cynthia M. Balion et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2007)

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The REALAB project: A new method for the formulation of reference intervals based on current data

E Grossi et al.

CLINICAL CHEMISTRY (2005)