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Heart Disease and Stroke Statistics-2022 Update: A Report From the American Heart Association

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AMERICAN JOURNAL OF KIDNEY DISEASES (2021)

Article Public, Environmental & Occupational Health

E-Cigarette Use and Adult Cigarette Smoking Cessation: A Meta-Analysis

Richard J. Wang et al.

Summary: Observational studies showed no association between e-cigarette use and smoking cessation in adult smokers. However, daily e-cigarette use was related to more quitting while less-than-daily use was related to less quitting. Randomized clinical trials indicated that providing e-cigarettes was associated with increased smoking cessation compared to conventional therapy.

AMERICAN JOURNAL OF PUBLIC HEALTH (2021)

Article Hematology

Conventional and Novel Lipid Measures and Risk of Peripheral Artery Disease

Minghao Kou et al.

Summary: Triglyceride-related and HDL-related lipids were independently associated with incident PAD, indicating implications for preventive strategies. Principal component analysis identified three components related to PAD risk.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2021)

Article Cardiac & Cardiovascular Systems

Weight change during middle age and risk of stroke and coronary heart disease: The Japan Public Health Center?based Prospective Study

Koichi Kisanuki et al.

Summary: The study found that weight gain during middle age was associated with an increased risk of stroke in women and an increased risk of CHD in men. Weight loss was associated with an increased risk of stroke in both men and women.

ATHEROSCLEROSIS (2021)

Article Obstetrics & Gynecology

Risk of cardiovascular outcomes among women with endometriosis in the United Kingdom: a retrospective matched cohort study

K. Okoth et al.

Summary: The study shows that women with endometriosis have a higher risk of cardiovascular outcomes compared to those without the condition, particularly in terms of ischemic heart disease, cerebrovascular disease, and heart failure. Although the incidence of endometriosis has decreased over the years, the prevalence of the condition has been on the rise.

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2021)

Article Cardiac & Cardiovascular Systems

Combined effect of menopause and cardiovascular risk factors on death and cardiovascular disease: a cohort study

Yan Li et al.

Summary: The study suggests that early menopause might be a predictor of death and ischemic stroke. Additionally, there is a combined effect of early menopause and elevated risk factors on death and cardiovascular disease.

BMC CARDIOVASCULAR DISORDERS (2021)

Article Cardiac & Cardiovascular Systems

Cerebral Embolic Protection and Outcomes of Transcatheter Aortic Valve Replacement Results From the Transcatheter Valve Therapy Registry

Neel M. Butala et al.

Summary: This study used data from the TAVR registry to investigate the association between EPD use and in-hospital stroke in TAVR patients. While the primary analysis did not find a significant association, a secondary analysis showed a modestly lower risk of in-hospital stroke with EPD use. Further large-scale randomized controlled trials are needed to determine whether EPDs provide meaningful clinical benefit for TAVR patients.

CIRCULATION (2021)

Article Cardiac & Cardiovascular Systems

Gestational Diabetes History and Glucose Tolerance After Pregnancy Associated With Coronary Artery Calcium in Women During Midlife The CARDIA Study

Erica P. Gunderson et al.

Summary: This study found that women without a history of GD after childbirth had a gradually increasing risk of CAC with worsening glucose tolerance, while women with a history of GD had a two-fold higher risk of CAC across all glucose tolerance levels.

CIRCULATION (2021)

Article Cardiac & Cardiovascular Systems

Fruit and Vegetable Intake and Mortality Results From 2 Prospective Cohort Studies of US Men and Women and a Meta-Analysis of 26 Cohort Studies

Dong D. Wang et al.

Summary: The study found that consuming approximately 5 servings of fruits and vegetables per day was associated with lower total mortality and mortality from cancer, cardiovascular disease, and respiratory disease. Higher intake beyond this level did not provide additional risk reduction.

CIRCULATION (2021)

Article Cardiac & Cardiovascular Systems

Effect of Dapagliflozin on Clinical Outcomes in Patients With Chronic Kidney Disease, With and Without Cardiovascular Disease

John J. V. McMurray et al.

Summary: Dapagliflozin reduces the risk of kidney failure, death from cardiovascular causes or hospitalization for heart failure, and prolongs survival in people with chronic kidney disease, independently of the presence of concomitant cardiovascular disease, regardless of whether they have type 2 diabetes.

CIRCULATION (2021)

Article Cardiac & Cardiovascular Systems

Very High Coronary Artery Calcium (≥1000) and Association With Cardiovascular Disease Events, Non-Cardiovascular Disease Outcomes, and Mortality Results From MESA

Allison W. Peng et al.

Summary: Individuals with very high coronary artery calcium (CAC >= 1000) are at substantially higher risk for cardiovascular disease events, non-CVD outcomes, and mortality compared to those with lower CAC, with cardiovascular event rates similar to a stable treated secondary prevention population.

CIRCULATION (2021)

Article Environmental Sciences

Long-term exposure to ambient air pollution and metabolic syndrome in children and adolescents: A national cross-sectional study in China

Jing-Shu Zhang et al.

Summary: The study found that long-term exposure to PM2.5, PM10, and NO2 positively associated with the prevalence of MetS in children and adolescents, with stronger associations observed in boys.

ENVIRONMENT INTERNATIONAL (2021)

Review Environmental Sciences

Associations between metabolic syndrome and four heavy metals: A systematic review and meta-analysis

Ping Xu et al.

Summary: Research has found a positive association between heavy metal exposure and MetS, with participants exposed to heavy metals having a higher likelihood of developing MetS. Further studies are needed to explore the effects of individual metals and their interactions on the relationship between MetS and heavy metals.

ENVIRONMENTAL POLLUTION (2021)

Article Medicine, General & Internal

Long-term recurrence risk after a first venous thromboembolism in men and women under 50 years old: A French prospective cohort

Claire de Moreuil et al.

Summary: In patients with a first VTE under 50 years old, a first unprovoked episode and a family history of VTE, but not gender, were associated with a high risk of long-term recurrence.

EUROPEAN JOURNAL OF INTERNAL MEDICINE (2021)

Article Peripheral Vascular Disease

Blood Pressure and Risk of Cardiovascular Disease in UK Biobank A Mendelian Randomization Study

Eric Yuk Fai Wan et al.

Summary: The study used Mendelian randomization to evaluate the causal association between blood pressure and cardiovascular diseases. The results showed a linear positive causal association between genetically predicted blood pressure and cardiovascular diseases, including ischemic heart disease and stroke. This finding reinforces the clinical knowledge that lower blood pressure is better for reducing the risk of cardiovascular diseases.

HYPERTENSION (2021)

Article Neurosciences

Cigarette Smoking Status, Cigarette Exposure, and Duration of Abstinence Predicting Incident Dementia and Death: A Multistate Model Approach

Adrienne L. Johnson et al.

Summary: Current smoking increases the risk for both dementia and death, with dementia being more attributable to recent smoking than lifetime exposure. Smoking cessation at any age can help reduce these risks for cognitively healthy individuals.

JOURNAL OF ALZHEIMERS DISEASE (2021)

Article Nursing

Validity of Chronic Venous Disease Diagnoses and Epidemiology Using Validated Electronic Health Records From Primary Care: A Real-World Data Analysis

Erica Homs-Romero et al.

Summary: The study evaluated the validity of lower limb chronic venous disease diagnoses in a large electronic health record database in primary care in Catalonia, Spain, finding low prevalence and incidence rates compared to the literature, possibly due to underdiagnosis of CVD.

JOURNAL OF NURSING SCHOLARSHIP (2021)

Article Cardiac & Cardiovascular Systems

Clinical Impact of Contralateral Carotid Occlusion in Patients Undergoing Carotid Artery Revascularization

Anna K. Krawisz et al.

Summary: CCO remains an important predictor of increased risk among patients undergoing CEA, but not CAS. This study highlights the impact of CCO on outcomes of carotid revascularization procedures.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

Article Urology & Nephrology

Two-Week Burden of Arrhythmias across CKD Severity in a Large Community-Based Cohort: The ARIC Study

Esther D. Kim et al.

Summary: The study found a higher prevalence of atrial fibrillation and nonsustained ventricular tachycardia among older adults with more severe CKD. Albuminuria was associated with a higher prevalence of atrial fibrillation and nonsustained ventricular tachycardia, while eGFR was associated with the frequency of atrioventricular block.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

Article Urology & Nephrology

Effect of Kidney Function on Relationships between Lifestyle Behaviors and Mortality or Cardiovascular Outcomes: A Pooled Cohort Analysis

Sarah J. Schrauben et al.

Summary: Recommended healthy lifestyle behaviors are associated with reduced risks of death and cardiovascular disease events among individuals with or without reduced kidney function. The magnitude of risk reduction increases with greater numbers of these behaviors.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

Article Medicine, General & Internal

Glycemic Index, Glycemic Load, and Cardiovascular Disease and Mortality

David J. A. Jenkins et al.

Summary: In this study involving 137,851 participants from five continents aged between 35 and 70 years, it was found that a diet with a high glycemic index was associated with an increased risk of cardiovascular disease and death. Consuming a diet with a high glycemic index was linked to higher risk of major cardiovascular events and death, even among participants without preexisting cardiovascular disease.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Review Public, Environmental & Occupational Health

Objectively measured physical activity and all cause mortality: A systematic review and meta-analysis

Rema Ramakrishnan et al.

Summary: The use of objective measures of physical activity, such as accelerometers, pedometers, and doubly labeled water method, shows a strong negative association with all cause mortality. Current physical activity recommendations based on questionnaire data may underestimate the true reduction in mortality risk associated with physical activity.

PREVENTIVE MEDICINE (2021)

Review Radiology, Nuclear Medicine & Medical Imaging

Pulmonary Embolism and Deep Vein Thrombosis in COVID-19: A Systematic Review and Meta-Analysis

Young Joo Suh et al.

Summary: In patients with COVID-19, the incidence rates of PE and DVT were 16.5% and 14.8%, respectively, with over half of PE patients lacking DVT. The cutoff values of D-dimer levels seem applicable to patients with COVID-19.

RADIOLOGY (2021)

Article Clinical Neurology

Time to Thrombolysis and Long-Term Outcomes in Patients With Acute Ischemic Stroke A Nationwide Study

Adelina Yafasova et al.

Summary: This study investigated the impact of time to thrombolysis on long-term outcomes in patients with first-time ischemic stroke. The findings showed that a longer time to thrombolysis was associated with an increased rate of death and recurrent ischemic stroke.

STROKE (2021)

Article Multidisciplinary Sciences

Genetic determinants of daytime napping and effects on cardiometabolic health

Hassan S. Dashti et al.

Summary: Daytime napping is a common heritable behavior, with potential causal links to cardiometabolic health. Genome-wide association studies have identified multiple loci associated with sleep and obesity-related genes, indicating a complex genetic basis for daytime napping and its impact on health outcomes.

NATURE COMMUNICATIONS (2021)

Article Environmental Sciences

A Pandemic within the Pandemic? Physical Activity Levels Substantially Decreased in Countries Affected by COVID-19

Jan Wilke et al.

Summary: During the COVID-19 pandemic, there was a significant decrease in physical activity levels globally, leading to a reduction in the number of people meeting the World Health Organization guidelines. The study found that reductions in occupational physical activity were higher than leisure time, and the decrease was more pronounced in young and old individuals compared to middle-aged persons.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

Article Orthopedics

Incidence and locations of preoperative deep venous thrombosis (DVT) of lower extremity following tibial plateau fractures: a prospective cohort study

Yanbin Zhu et al.

Summary: Through studying 192 patients with tibial plateau fractures, it was found that the incidence rate of DVT was 16.3%, with 1.0% for proximal DVT and 15.3% for distal DVT. Six risk factors including gender, hypertension, open fracture, alkaline phosphatase, sodium concentration, and D-dimer were identified to be associated with DVT.

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH (2021)

Article Cardiac & Cardiovascular Systems

Association Between Asymptomatic Proximal Deep Vein Thrombosis and Mortality in Acutely Ill Medical Patients

Gary E. Raskob et al.

Summary: The study found a significant association between asymptomatic proximal deep vein thrombosis (DVT) and all-cause mortality, with a higher mortality rate compared to patients without VTE, similar to symptomatic VTE. This suggests that asymptomatic proximal DVT remains an important endpoint in evaluating the efficacy of anticoagulant thromboprophylaxis in medical patients.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

Article Cardiac & Cardiovascular Systems

Coronavirus Disease 2019 Hospitalizations Attributable to Cardiometabolic Conditions in the United States: A Comparative Risk Assessment Analysis

Meghan O'Hearn et al.

Summary: A significant proportion of COVID-19 hospitalizations in US adults can be attributed to major cardiometabolic conditions. These findings can contribute to the development of public health strategies aimed at reducing the healthcare burden of COVID-19.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

Article Clinical Neurology

Association of Intensive vs Standard Blood Pressure Control With Magnetic Resonance Imaging Biomarkers of Alzheimer Disease Secondary Analysis of the SPRINT MIND Randomized Trial

Ilya M. Nasrallah et al.

Summary: This study evaluated the impact of intensive blood pressure control on AD-related brain biomarkers, finding a greater decrease in hippocampal volume in the intensive treatment group compared to standard treatment. However, there were no significant differences in other MRI biomarkers of AD between the two treatment groups.

JAMA NEUROLOGY (2021)

Article Clinical Neurology

Burden of Neurological Disorders Across the US From 1990-2017 A Global Burden of Disease Study

Valery L. Feigin et al.

Summary: There is a large and increasing burden of noncommunicable neurological disorders in the US, with up to a 5-fold variation in the burden of and trends in particular neurological disorders across the US states. The information reported in this article can be used by health care professionals and policy makers at the national and state levels to advance their health care planning and resource allocation to prevent and reduce the burden of neurological disorders.

JAMA NEUROLOGY (2021)

Article Pediatrics

Association of Eviction With Adverse Birth Outcomes Among Women in Georgia, 2000 to 2016

Gracie Himmelstein et al.

Summary: This study found that eviction actions during pregnancy are associated with adverse birth outcomes, including lower birth weight, increased rates of low birth weight and prematurity, and a potential increase in mortality. Providing housing, social, and medical assistance to pregnant women at risk for eviction may improve infant health.

JAMA PEDIATRICS (2021)

Article Clinical Neurology

Residual Risk and Its Risk Factors for Ischemic Stroke with Adherence to Guideline-Based Secondary Stroke Prevention

Yuesong Pan et al.

Summary: Despite adherence to guideline-based secondary stroke prevention, there is still a significant residual risk of recurrent stroke at 12 months. Future research should focus on reducing this residual risk.

JOURNAL OF STROKE (2021)

Article Cardiac & Cardiovascular Systems

Value of Coronary Artery Calcium Scanning in Association With the Net Benefit of Aspirin in Primary Prevention of Atherosclerotic Cardiovascular Disease

Ezimamaka Ajufo et al.

Summary: Coronary artery calcium score is associated with bleeding and atherosclerotic cardiovascular disease events, with higher scores identifying individuals who may benefit from aspirin therapy, particularly in the setting of lower bleeding risk and non-low estimated ASCVD risk.

JAMA CARDIOLOGY (2021)

Article Cardiac & Cardiovascular Systems

Screening for Atrial Fibrillation in the Older Population A Randomized Clinical Trial

David J. Gladstone et al.

Summary: In this study, home-based AF screening with a wearable cECG monitor significantly increased AF detection and anticoagulant therapy initiation, especially in older community-dwelling individuals with hypertension. Intermittent oscillometric screening with a BP monitor was found to be less effective for detecting paroxysmal AF compared to continuous ECG monitoring. Further large trials are needed to evaluate the benefits and risks of AF screening with hard clinical outcomes.

JAMA CARDIOLOGY (2021)

Article Medicine, General & Internal

Comparison of Diabetes Medications Used by Adults With Commercial Insurance vs Medicare Advantage, 2016 to 2019

Rozalina G. McCoy et al.

Summary: This study showed that initiation rates of newer medications to lower glucose levels were higher among commercially insured beneficiaries compared to Medicare Advantage beneficiaries, especially among lower-income patients. Further efforts may be needed to promote greater equity in diabetes management.

JAMA NETWORK OPEN (2021)

Article Cardiac & Cardiovascular Systems

Meta-Analysis of Atrial Fibrillation in Patients With COVID-19

Haiyan Yang et al.

AMERICAN JOURNAL OF CARDIOLOGY (2021)

Article Endocrinology & Metabolism

Does the built environment have independent obesogenic power? Urban form and trajectories of weight gain

James H. Buszkiewicz et al.

Summary: The study found that built environment variables were associated with baseline obesity prevalence and body mass index, but had limited impact on weight trajectories over time. Adjusted regression models showed that higher density metrics and frequency counts were associated with lower weight gain at the 5-year follow-up.

INTERNATIONAL JOURNAL OF OBESITY (2021)

Article Clinical Neurology

Cardiovascular Risk Factors Across the Life Course and Cognitive Decline A Pooled Cohort Study

Kristine Yaffe et al.

Summary: The study found that the accumulation of cardiovascular risk factors, especially early adulthood, is associated with late-life cognitive decline. The associations for early adult and late-life cardiovascular risk factors persisted after adjusting for exposures at all time periods.

NEUROLOGY (2021)

Article Multidisciplinary Sciences

Baseline cardiometabolic profiles and SARS-CoV-2 infection in the UK Biobank

Ryan J. Scalsky et al.

Summary: This study found that higher BMI, type II diabetes, and HbA1c levels were associated with increased odds of testing positive for SARS-CoV-2, while elevated HDL-C and ApoA-I levels were associated with reduced odds. The effects of BMI, type II diabetes, and HbA1c levels may be mediated in part through regulation of HDL-C levels.

PLOS ONE (2021)

Article Cardiac & Cardiovascular Systems

Warranty Period of a Calcium Score of Zero Comprehensive Analysis From MESA

Omar Dzaye et al.

Summary: This study provides a robust estimation of the warranty period for CAC = 0, considering progression to CAC >0, CAC >10, and CAC >100 and its impact on missed versus detectable 10-year coronary heart disease events in a large population. Beyond age, sex, race/ethnicity, diabetes also has a significant impact on the warranty period. Evidence-based guidance would be to consider rescanning in 3 to 7 years depending on individual demographics and risk profile.

JACC-CARDIOVASCULAR IMAGING (2021)

Article Multidisciplinary Sciences

Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices

Pradeep Natarajan et al.

Summary: The study analyzed X chromosome sequencing data in over 65,000 multi-ancestry individuals, identifying associations of the Xq23 locus with lipid changes and reduced risk of CHD and type 2 diabetes.

NATURE COMMUNICATIONS (2021)

Article Cardiac & Cardiovascular Systems

Estimated Impact of Achieving Optimal Cardiovascular Health Among US Adults on Cardiovascular Disease Events

Joshua D. Bundy et al.

Summary: This study found that only about 7.3% of US adults have high levels of cardiovascular health. The results suggest that if all US adults achieve high levels of cardiovascular health, 2.0 million cardiovascular events could be prevented annually.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

Article Pediatrics

Association of Preterm Birth With Long-term Risk of Heart Failure Into Adulthood

Casey Crump et al.

Summary: This study found that preterm birth is associated with an increased risk of heart failure from childhood into mid-adulthood. The risk appears to be explained by shared determinants of preterm birth and heart failure within families, especially in adulthood.

JAMA PEDIATRICS (2021)

Article Medicine, General & Internal

Prevalence of Hypertension Among Pregnant Women When Using the 2017 American College of Cardiology/American Heart Association Blood Pressure Guidelines and Association With Maternal and Fetal Outcomes

Natalie A. Bello et al.

Summary: This study compared the effects of using ACC/AHA and ACOG guidelines for defining hypertension in pregnant women. Results showed that using the ACC/AHA criteria led to better identification of women at risk for developing preeclampsia in the future.

JAMA NETWORK OPEN (2021)

Article Cardiac & Cardiovascular Systems

Population-Based Risk Factors for Ascending, Arch, Descending, and Abdominal Aortic Dilations for 60-74-Year-Old Individuals

Lasse M. Obel et al.

Summary: Aortic dilations may occur on any segment of the aorta, with varying pathogenesis and risk factors. This study found that the presence of coexisting aortic dilations is the most dominant predictor for dilations at any aortic segment.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

Article Clinical Neurology

Depressive Symptoms and Risk of Stroke in a National Cohort of Black and White Participants From REGARDS

Cassandra D. Ford et al.

Summary: The study found that the association of depressive symptoms with increased stroke risk was similar among Black and White participants, suggesting that assessment of depressive symptoms should be considered in primary stroke prevention for both groups.

NEUROLOGY-CLINICAL PRACTICE (2021)

Article Cardiac & Cardiovascular Systems

COVID-19 and congenital heart disease: an insight of pathophysiology and associated risks

Ana Alina Haiduc et al.

Summary: This systematic review suggests that patients with congenital heart disease may have a higher risk of poor outcomes when diagnosed with COVID-19, but further research with larger sample sizes is necessary to make a more justified conclusion.

CARDIOLOGY IN THE YOUNG (2021)

Article Obstetrics & Gynecology

What is driving the decreased incidence of preterm birth during the coronavirus disease 2019 pandemic?

Lara Lemon et al.

Summary: The incidence of preterm births has decreased during the COVID-19 pandemic, with decreases in spontaneous preterm births limited to deliveries to white women, living in more advantaged neighborhoods, and deliveries at nonoutpatient care facilities.

AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM (2021)

Review Medicine, General & Internal

Endothelin receptor antagonists for pulmonary arterial hypertension

Chao Liu et al.

Summary: Endothelin receptor antagonists are effective in improving exercise capacity, functional class, and cardiopulmonary variables in patients with pulmonary arterial hypertension, but may have limited effect on reducing dyspnoea and mortality. Close monitoring of liver function is necessary during treatment with ERAs. Further studies are needed to confirm the potential benefits of combined use of ERAs with phosphodiesterase inhibitors.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2021)

Article Cardiac & Cardiovascular Systems

Trends in cholesterol testing during the COVID-19 pandemic COVID-19 and cholesterol testing

Esra D. Gumuser et al.

Summary: This study showed a 39% decline in cholesterol testing rates in the Mass General Brigham healthcare system between March and September 2020 compared to the same period in 2019, with the greatest reductions seen during the first wave of the COVID-19 pandemic. Individuals tested during the first wave had significantly lower total cholesterol levels compared to those tested later in the 2020 period.

AMERICAN JOURNAL OF PREVENTIVE CARDIOLOGY (2021)

Article Sport Sciences

Are physical activity and sedentary behavior patterns contributing to diabetes and metabolic syndrome simultaneously?

Benjamin H. Colpitts et al.

Summary: The study found that engaging in moderate-to-vigorous intensity physical activity is more important than reducing sedentary time in lowering the odds of developing MetS and diabetes. Associations between sedentary behavior patterns and the conditions were weak compared to the importance of physical activity.

TRANSLATIONAL SPORTS MEDICINE (2021)

Article Cardiac & Cardiovascular Systems

Out-of-Hospital Cardiac Arrest Response and Outcomes During the COVID-19 Pandemic

Audrey Uy-Evanado et al.

Summary: This study evaluated the impact of the COVID-19 pandemic on out-of-hospital cardiac arrest responses and outcomes in two U.S. communities with relatively low infection rates. The results show that the pandemic led to decreased bystander CPR and AED use, longer EMS response time, and reduced survival rates in these communities.

JACC-CLINICAL ELECTROPHYSIOLOGY (2021)

Article Cardiac & Cardiovascular Systems

International Impact of COVID-19 on the Diagnosis of Heart Disease

Andrew J. Einstein et al.

Summary: The COVID-19 pandemic has significantly reduced cardiovascular diagnostic testing globally, especially affecting economically challenged regions. Further research on cardiovascular outcomes and changes in care delivery due to COVID-19 is needed.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

Article Endocrinology & Metabolism

Association of TNF-α-308 G>A (rs1800629) polymorphism with susceptibility of metabolic syndrome

Dalia Ghareeb et al.

Summary: This study found a significant association between TNF-alpha-308 G > A (rs1800629) polymorphism and susceptibility to metabolic syndrome, with the A allele being a strong predictor in Egyptians. Positive correlations were also observed between the TNF-alpha-308 (G/A) polymorphism and risk factors of metabolic syndrome such as body mass index, fasting blood sugar, cholesterol, and low density lipoprotein.

JOURNAL OF DIABETES AND METABOLIC DISORDERS (2021)

Article Public, Environmental & Occupational Health

The First Global Physical Activity and Sedentary Behavior Guidelines for People Living With Disability

Catherine Carty et al.

Summary: The World Health Organization has released global public health guidelines on physical activity and sedentary behavior for people living with disability, highlighting the overall benefits of physical activity outweighing the risks for individuals with disabilities, as well as emphasizing the benefits of limiting sedentary behavior.

JOURNAL OF PHYSICAL ACTIVITY & HEALTH (2021)

Article Cardiac & Cardiovascular Systems

Hydroxychloroquine/Azithromycin Therapy and QT Prolongation in Hospitalized Patients With COVID-19

Thomas F. O'Connell et al.

Summary: This study characterized QTc prolongation in hospitalized COVID-19 patients treated with HCQ/AZM. Several clinical factors were associated with greater QTc prolongation, but changes in QTc were not linked to increased risk of death.

JACC-CLINICAL ELECTROPHYSIOLOGY (2021)

Article Cardiac & Cardiovascular Systems

Atrial fibrillation and the risk of 30-day incident thromboembolic events, and mortality in adults ≥ 50 years with COVID-19

Stephanie L. Harrison et al.

Summary: The study suggests that atrial fibrillation could be an important risk factor for short-term mortality with COVID-19, and COVID-19 may increase the risk of short-term mortality among adults with AF.

JOURNAL OF ARRHYTHMIA (2021)

Article Gastroenterology & Hepatology

Adherence to Ideal Cardiovascular Health Metrics Is Associated With Reduced Odds of Hepatic Steatosis

Leah R. DeCoste et al.

Summary: Adhering to the AHA Life's Simple 7 metrics was associated with reduced odds of prevalent NAFLD, particularly for those at high genetic risk. BMI had the strongest association with NAFLD, and individuals with high or intermediate genetic risk showed higher relative decreases in hepatic steatosis with increased CHS.

HEPATOLOGY COMMUNICATIONS (2021)

Article Pediatrics

Congenital heart diseases and parental occupational exposure in a Hungarian case-control study in 1997 to 2002

Vince Fazekas-Pongor et al.

Summary: The study identified a positive association between paternal occupational exposure to pesticides and alkylphenolic compounds and the development of patent ductus arteriosus in the offspring. Alkylphenolic compound exposure was found among painters, farmers, and those working in the food service industry, while pesticide exposure occurred predominantly among farm workers. Certain occupations may increase the occurrence of specific congenital heart disease phenotypes in the offspring, highlighting the importance of closer monitoring and antenatal detection in these at-risk populations.

CONGENITAL ANOMALIES (2021)

Article Public, Environmental & Occupational Health

Regional factors associated with the prevalence of metabolic syndrome: Focusing on the role of healthcare providers

Kyu-Tae Han et al.

Summary: This study found that a higher density of physicians was associated with a lower prevalence of MetS. While the density of community health nurses was not significantly associated with MetS prevalence overall, higher densities of physicians and community health nurses were found to be significantly associated with a lower prevalence of MetS in regions with a high proportion of community health centres.

HEALTH & SOCIAL CARE IN THE COMMUNITY (2021)

Article Cardiac & Cardiovascular Systems

CHARGE-AF in a national routine primary care electronic health records database in the Netherlands: validation for 5-year risk of atrial fibrillation and implications for patient selection in atrial fibrillation screening

Jelle C. L. Himmelreich et al.

Summary: This study validated the effectiveness of the CHARGE-AF model in a Dutch routine primary care database and demonstrated its potential for automated, low-cost selection of high-risk AF patients. The results showed that CHARGE-AF outperformed other predictors in assessing AF risk, and different CHARGE-AF cut-offs had merits for patient selection in screening efforts.

OPEN HEART (2021)

Article Geriatrics & Gerontology

The Relationship of Accelerometer-Assessed Standing Time With and Without Ambulation and Mortality: The WHI OPACH Study

Purva Jain et al.

Summary: This prospective study among older women found that higher levels of accelerometer-measured standing were associated with lower risks of all-cause mortality. Standing is a feasible approach to interrupting prolonged sedentary time and appears to benefit health in older ages.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2021)

Review Medicine, General & Internal

Thrombolytic strategies versus standard anticoagulation for acute deep vein thrombosis of the lower limb

Cathryn Broderick et al.

Summary: Thrombolytic therapy aids in complete dissolution of clots and slightly reduces the incidence of post-thrombotic syndrome, but also increases the risk of bleeding. Systemic thrombolysis and CDT show similar efficacy, and further research is needed to explore treatment regimens.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2021)

Article Cardiac & Cardiovascular Systems

Long-Term All-Cause and Cause-Specific Mortality in Asymptomatic Patients With CAC ≥1,000 Results From the CAC Consortium

Allison W. Peng et al.

JACC-CARDIOVASCULAR IMAGING (2020)

Article Emergency Medicine

Narrowing performance gap between rural and urban hospitals for acute myocardial infarction care

Fares Alghanem et al.

AMERICAN JOURNAL OF EMERGENCY MEDICINE (2020)

Article Cardiac & Cardiovascular Systems

Cardiovascular impact of electronic-cigarette use

Holly R. Middlekauff

TRENDS IN CARDIOVASCULAR MEDICINE (2020)

Article Rehabilitation

The Impact of One's Sex and Social Living Situation on Rehabilitation Outcomes After a Stroke

Catherine Cooper Hay et al.

AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION (2020)

Article Cardiac & Cardiovascular Systems

Sex differences in the association of risk factors for heart failure incidence and mortality

Anne Sillars et al.

Article Cardiac & Cardiovascular Systems

2017 ACC/AHA blood pressure classification and incident peripheral artery disease: The Atherosclerosis Risk in Communities (ARIC) Study

Yifei Lu et al.

EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY (2020)

Article Cardiac & Cardiovascular Systems

Relations Between Physical Activity, Subclinical Myocardial Injury, and Cardiovascular Mortality in the General Population

Charles German et al.

AMERICAN JOURNAL OF CARDIOLOGY (2020)

Review Rehabilitation

Exercise Programs Delivered According to Guidelines Improve Mobility in People With Stroke: A Systematic Review and Meta-analysis

Dina Pogrebnoy et al.

ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION (2020)

Article Critical Care Medicine

Racial and Ethnic Disparities in Postcardiac Arrest Targeted Temperature Management Outcomes*

Claire S. Jacobs et al.

CRITICAL CARE MEDICINE (2020)

Article Cardiac & Cardiovascular Systems

Incidence of deep vein thrombosis from screening by venous ultrasonography in Japanese patients

Yu Morishita et al.

HEART AND VESSELS (2020)

Article Peripheral Vascular Disease

The association of dietary phosphorus with blood pressure: results from a secondary analysis of the PREMIER trial

Scott T. McClure et al.

JOURNAL OF HUMAN HYPERTENSION (2020)

Article Neuroimaging

National trends in endovascular therapy for acute ischemic stroke: utilization and outcomes

Laura Stein et al.

JOURNAL OF NEUROINTERVENTIONAL SURGERY (2020)

Article Hospitality, Leisure, Sport & Tourism

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Bicuspid aortic valve is heritable

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