4.3 Article

Relationships between endogenous circadian period, physiological and cognitive parameters and sex in aged gray mouse lemurs (Microcebus murinus)

期刊

CHRONOBIOLOGY INTERNATIONAL
卷 39, 期 3, 页码 363-373

出版社

TAYLOR & FRANCIS INC
DOI: 10.1080/07420528.2021.2001478

关键词

Biological clock; circadian resonance; aging; metabolism; cognition

资金

  1. Human Frontier Science Program

向作者/读者索取更多资源

This study examined the relationship between endogenous period and biomarkers of aging, finding that a deviation of endogenous period from 24 h led to increased oxidative stress, decreased IGF-1 concentrations, and impaired learning performances. These results support the circadian resonance theory, demonstrating a connection between endogenous period and lifespan, aging, and biological performance.
The biological clock generates circadian rhythms, with an endogenous period tau close to 24 h. The circadian resonance theory proposes that lifespan is reduced when endogenous period goes far from 24 h. It has been suggested that daily resetting of the circadian clock to the 24 h external photoperiod might induce marginal costs that would accumulate over time and forward accelerate aging and affect fitness. In this study, we aimed to evaluate the link between the endogenous period and biomarkers of aging in order to investigate the mechanisms of the circadian resonance theory. We studied 39 middle-aged and aged Microcebus murinus, a nocturnal non-human primate whose endogenous period is about 23.1 h, measuring the endogenous period of locomotor activity, as well as several physiological and behavioral parameters (rhythm fragmentation and amplitude, energetic expenditure, oxidative stress, insulin-like growth factor-1 (IGF-1) concentrations and cognitive performances) in both males and females. We found that aged males with tau far from 24 h displayed increased oxidative stress. We also demonstrated a positive correlation between tau and IGF-1 concentrations, as well as learning performances, in males and females. Together these results suggest that a great deviation of tau from 24 h leads to increased biomarkers of age-related impairments.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.3
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据