期刊
CHINESE CHEMICAL LETTERS
卷 33, 期 6, 页码 3277-3280出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2021.11.004
关键词
Photodynamic therapy; Polymeric micelle; BODIPY; 2-Pyridone; Tumor
资金
- Shanghai Sailing Program [20YF14580 00]
Photodynamic therapy (PDT) is a promising non-invasive and targeted treatment approach. However, the hypoxic microenvironment in tumor tissue limits its effectiveness. In this study, a novel photosensitizer-loaded polymer system was developed, which significantly inhibited tumor proliferation, demonstrating its potential as an effective photo therapeutic system for cancer treatment.
Photodynamic therapy (PDT) has been gaining popularity in both scientific research and clinic applications due to its non-invasiveness and spatiotemporal targeting properties. Nevertheless, the local hypoxic microenvironment in tumor tissue impedes PDT universality. To overcome this drawback, a 2-pyridone-bearing BODIPY photosensitizer was synthesized rationally and introduced to polyethyleneglycol-b-poly(aspartic acid) to form a photosensitizer-O-1(2) generation, storage/release agent dual-loading system (PEG-b-PAsp-BODIPY). The investigation of the PDT effect at different illumination conditions in vitro and in vivo revealed that the system tremendously inhibited tumor proliferation, indicating that this new PEG-b-PAsp-BODIPY could act as a potentially effective photo therapeutic system for cancer therapeutics. (C) 2022 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
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