期刊
CHINESE CHEMICAL LETTERS
卷 33, 期 4, 页码 1861-1864出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2021.10.024
关键词
Aggregation-induced emission; Excited state intramolecular proton transfer; Photoinduced electron transfer; Mercury ions; Fluorescent imaging
In this study, a novel fluorescent probe was developed for efficient detection of Hg2+ by combining aggregation-induced emission and excited state intramolecular proton transfer characteristics. The probe exhibited good selectivity, short response time, and a low detection limit. Its successful application in real samples, cells, and drug evaluation demonstrated its superiority in practical Hg2+ detection.
Excessive mercury ions (Hg2+) in the environment can accumulate in human body along with the food chain to cause serious physiological reactions. The fluorescence probes were considered as convenient tool with great potential for Hg2+ detection. Most existing probes suffer from aggregation-induced quenching (ACQ) effects and insufficient sensitivity. Herein, a novel type of fluorophore was developed by combining the aggregation-induced emission (AIE) and excited state intramolecular proton transfer (ESIPT) characteristics. Subsequently, a phenyl thioformate group with photoinduced electron transfer (PET) effect was connected to give an efficient turn-on probe (HTM), which exhibited good selectivity toward Hg2+, short response time (30 min), coupled with extremely low detection limit (LOD = 1.68 nmol/L). In addition, HTM was used successfully in real samples, cells and drug evaluation, underlying the superiority of HTM to detect Hg2+ in practical applications. (C) 2021 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
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