NFSI-catalyzed S-S bond exchange reaction for the synthesis of unsymmetrical disulfides

The metal free S-S bond exchange reaction of symmetrical disulfides catalyzed by NFSI is described. This novel protocol provides a facile and efficient approach to accessing important unsymmetrical disulfides. Furthermore, this strategy could also be utilized in the late-stage functionalization of amino acids, drugs, and natural products. The broad substrate scope, good functional group tolerance and easy accessibility of catalyst indicate that this strategy affords a green and practical complementary method to various unsymmetrical disulfides. (C) 2022 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.

Automated summary

The metal-free S-S bond exchange reaction of symmetrical disulfides catalyzed by NFSI is a novel and efficient approach to accessing important unsymmetrical disulfides. This strategy can also be applied in the late-stage functionalization of amino acids, drugs, and natural products. The broad substrate scope, good functional group tolerance, and easy accessibility of the catalyst make this strategy a green and practical complementary method for synthesizing various unsymmetrical disulfides.