Blue light-promoted cyclopropenizations of N-tosylhydrazones in water

Carbene transfer reactions play an important role in the field of organic synthesis because of their ability to construct a variety of molecules. Herein, we reported on blue light-induced cyclopropenizations of N-tosylhydrazones in water, which avoids the use of expensive metal-based catalysts and toxic organic solvents. This metal-free and operationally simple methodology enable highly efficient cyclopropenizations, X-H insertion reactions, and cyclopropanation under mild reaction conditions. (C) 2021 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.

Automated summary

Carbene transfer reactions are important in organic synthesis for constructing a variety of molecules. In this study, a metal-free and operationally simple methodology for blue light-induced cyclopropenizations of N-tosylhydrazones in water was reported, enabling highly efficient reactions under mild conditions.