Hexafluoroisopropanol-Promoted or Bronsted Acid-Mediated Photochemical [2+2] Cycloadditions of Alkynes with Maleimides

Article Oncology

Impact of the addition of carboplatin to anthracycline-taxane-based neoadjuvant chemotherapy on survival inBRCA1/2-mutated triple-negative breast cancer

Juan Zhang et al.

Summary: This study found that in BRCA1/2-mutated triple-negative breast cancer, adding carboplatin to the standard A-T chemotherapy regimen can improve survival rates for patients.

INTERNATIONAL JOURNAL OF CANCER (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Hexafluoroisopropanol-Promoted Haloamidation and Halolactonization of Unactivated Alkenes

Chenxiao Qi et al.

Summary: A novel method for haloamidation is introduced in this paper, providing new building blocks for drug discovery. This method overcomes some limitations of traditional reactions and the reaction mechanism is deeply studied, which is expected to promote the development of more complex transformations in this field.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Photocatalyzed Intramolecular [2+2] Cycloaddition of N-Alkyl-N-(2-(1-arylvinyl)aryl)cinnamamides

Wanderson C. de Souza et al.

Summary: N-Alkyl-N-(2-(1-arylvinyl)aryl)cinnamamides can be converted into natural product inspired scaffolds via iridium photocatalyzed intramolecular [2+2] photocycloaddition, allowing the synthesis of a variety of tetrahydrocyclobuta[c]quinolin-3(1H)-ones with high molecular complexity.

CHEMISTRY-A EUROPEAN JOURNAL (2021)

添加到收藏夹

Article Chemistry, Physical

Highly Efficient Iridium-Based Photosensitizers for Thia-Paterno-Buchi Reaction and Aza-Photocyclization

Jian He et al.

Summary: Substrates in excited state differ significantly from the corresponding ground state, making photocatalytic systems increasingly popular for activation of substrates. By optimizing the properties of photosensitizers, a series of iridium complexes with high performance were successfully designed for various challenging photocycloaddition reactions.

ACS CATALYSIS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Time-Resolved EPR Revealed the Formation, Structure, and Reactivity of N-Centered Radicals in an Electrochemical C(sp3)-H Arylation Reaction

Yichang Liu et al.

Summary: Electrochemical synthesis has rapidly developed in recent years, with the majority of reactions proceeding through a radical pathway. Understanding the properties of radical intermediates is crucial for mechanistic studies and developing new reactions. This study directly researched the formation and structure of sulfonamide N-centered radicals using the time-resolved EPR technique under electrochemical conditions, and successfully applied the results in the discovery of an unactivated C(sp(3))-H arylation reaction.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Intermolecular Crossed [2+2] Cycloaddition Promoted by Visible-Light Triplet Photosensitization: Expedient Access to Polysubstituted 2-Oxaspiro[3.3]heptanes

Philip R. D. Murray et al.

Summary: This paper presents an intermolecular cross-selective [2 + 2] photocycloaddition reaction, demonstrating the synthesis of polysubstituted organic compounds with potential applications in medicinal chemistry. Further transformations of the primary products enable selective access to syn- or anti-diastereoisomers. Experimental and theoretical investigations reveal a sensitized energy transfer pathway in this reaction.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

添加到收藏夹

Review Multidisciplinary Sciences

Emerging concepts in photocatalytic organic synthesis

Susanne Reischauer et al.

Summary: Researchers have improved photocatalysts by adjusting the wavelength and intensity to control or change the selectivity of chemical reactions. In addition, recent efforts have focused on substituting strong reductants, such as elemental lithium and sodium, with light and technological advancements.

ISCIENCE (2021)

添加到收藏夹

Article Chemistry, Organic

Construction of Complex Cyclobutane Building Blocks by Photosensitized [2+2] Cycloaddition of Vinyl Boronate Esters

Spencer O. Scholz et al.

Summary: This study presents a photosensitized [2 + 2] cycloaddition reaction for the straightforward access to complex cyclobutane scaffolds. Mechanistic studies suggest an activation mode involving energy transfer to the styrenyl alkene rather than the vinyl boronate ester.

ORGANIC LETTERS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Photochemical intermolecular dearomative cycloaddition of bicyclic azaarenes with alkenes

Jiajia Ma et al.

Summary: This study reveals a new energy transfer-mediated, highly selective dearomative cycloaddition reaction of bicyclic azaarenes with diverse alkenes. By bypassing the low reactivity and selectivity challenges of aromatic systems, this approach provides access to bridged polycycles that were previously inaccessible or required complex synthetic efforts. Computational studies using density functional theory help elucidate the mechanism and selectivity of this reaction.

SCIENCE (2021)

添加到收藏夹

Review Chemistry, Organic

Thioxanthone: a powerful photocatalyst for organic reactions

Nikolaos F. Nikitas et al.

Summary: Photoorganocatalysis is recognized as an important aspect of photochemistry and catalysis in organic chemistry, with aromatic ketones playing a significant role. Thioxanthone (TX) stands out for its unique properties in photochemistry, with high triplet energy and long triplet lifetime, making it effective in merger reactions with metal complexes. This review discusses the photophysical properties of TX and its applications in various photochemical reactions, particularly in polymerization and organic transformations.

ORGANIC & BIOMOLECULAR CHEMISTRY (2021)

添加到收藏夹

Article Chemistry, Organic

HFIP-mediated 2-aza-Cope rearrangement: metal-free synthesis of α-substituted homoallylamines at ambient temperature

Karthik Gadde et al.

Summary: An efficient metal-free strategy has been developed for the synthesis of alpha-substituted homoallylamine derivatives via a 2-aza-Cope rearrangement promoted by HFIP. This method provides rapid access to the desired products with excellent functional group tolerance and high yields, without the need for chromatographic purification. The synthetic utility of this method is further demonstrated through the transformation of benzophenone ketimines into various compounds.

ORGANIC & BIOMOLECULAR CHEMISTRY (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Hexafluoroisopropanol: the magical solvent for Pd-catalyzed C-H activation

Trisha Bhattacharya et al.

Summary: HFIP, as a solvent, plays a unique role in Pd-catalyzed C-H functionalization reactions, especially in enhancing yield and selectivity, making it irreplaceable.

CHEMICAL SCIENCE (2021)

添加到收藏夹

Article Chemistry, Organic

Energy Transfer Catalysis by Visible Light: Atrop- and Regio-Selective Intermolecular [2+2]-Photocycloaddition of Maleimide with Alkenes

Sapna Ahuja et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Green Metal-Free Photochemical Hydroacylation of Unactivated Olefins

Errika Voutyritsa et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

添加到收藏夹

Article Plant Sciences

Orthoscuticellines A-E, β-Carboline Alkaloids from the Bryozoan Orthoscuticella ventricosa Collected in Australia

Guy Kleks et al.

JOURNAL OF NATURAL PRODUCTS (2020)

添加到收藏夹

Review Chemistry, Organic

Aldehydes as powerful initiators for photochemical transformations

Maria A. Theodoropoulou et al.

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Alkyne-Alkene [2+2] cycloaddition based on visible light photocatalysis

Sujin Ha et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Chemistry, Physical

2,5-Diketopiperazine Catalysts as Activators of Dioxygen in Oxidative Processes

Marina Petsi et al.

ACS CATALYSIS (2020)

添加到收藏夹

Article Chemistry, Organic

Divergent Photocatalytic Reactions of α-Ketoesters under Triplet Sensitization and Photoredox Conditions

Jian Zheng et al.

ORGANIC LETTERS (2020)

添加到收藏夹

Article Chemistry, Organic

Visible-Light-Enabled Paterno-Buchi Reaction via Triplet Energy Transfer for the Synthesis of Oxetanes

Katie A. Rykaczewski et al.

ORGANIC LETTERS (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Synthesis of azetidines via visible-light-mediated intermolecular [2+2] photocycloadditions

Marc R. Becker et al.

NATURE CHEMISTRY (2020)

添加到收藏夹

Article Oncology

Lobaplatin-Based Hyperthermic Intraperitoneal Chemotherapy for Patients with Peritoneal Metastasis from Appendiceal and Colorectal Cancer: Safety and Efficacy Profiles

Wei Pei et al.

CANCER MANAGEMENT AND RESEARCH (2020)

添加到收藏夹

Review Electrochemistry

Review-Use of 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) Co-Solvent Mixtures in Organic Electrosynthesis

Jose Manuel Ramos-Villasenor et al.

JOURNAL OF THE ELECTROCHEMICAL SOCIETY (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Photochemical synthesis of acetals utilizing Schreiner's thiourea as the catalyst

Nikoleta Spiliopoulou et al.

GREEN CHEMISTRY (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Photochemical oxidation of benzylic primary and secondary alcohols utilizing air as the oxidant

Nikolaos F. Nikitas et al.

GREEN CHEMISTRY (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Bronsted acid catalysis of photosensitized cycloadditions

Evan M. Sherbrook et al.

CHEMICAL SCIENCE (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Catalyst-Free Deaminative Functionalizations of Primary Amines by Photoinduced Single-Electron Transfer

Jingjing Wu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Sequential Photochemical and Prins Reactions for the Diastereo-selective Synthesis of Tricyclic Scaffolds

Bethan L. Donnelly et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Intramolecular [2+2] Photocycloaddition of Cyclic Enones: Selectivity Control by Lewis Acids and Mechanistic Implications

Saner Poplata et al.

CHEMISTRY-A EUROPEAN JOURNAL (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Practical and regioselective amination of arenes using alkyl amines

Alessandro Ruffoni et al.

NATURE CHEMISTRY (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Visible-Light-Photosensitized Aryl and Alkyl Decarboxylative Functionalization Reactions

Tuhin Patra et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Enantioselective [2+2] Cycloadditions of Cinnamate Esters: Generalizing Lewis Acid Catalysis of Triplet Energy Transfer

Mary Elisabeth Daub et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Discovery of Unforeseen Energy-Transfer-Based Transformations Using a Combined Screening Approach

Felix Strieth-Kalthoff et al.

CHEM (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Enantioselective Intermolecular Excited-State Photoreactions Using a Chiral Ir Triplet Sensitizer: Separating Association from Energy Transfer in Asymmetric Photocatalysis

Jian Zheng et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

添加到收藏夹

Article Chemistry, Organic

Solvent Control in Electro-Organic Synthesis

Lara Schulz et al.

SYNLETT (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Photo-organocatalytic synthesis of acetals from aldehydes

Nikolaos F. Nikitas et al.

GREEN CHEMISTRY (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Reversal of reaction type selectivity by Lewis acid coordination: the ortho photocycloaddition of 1-and 2-naphthaldehyde

Simone Stegbauer et al.

CHEMICAL SCIENCE (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Interplay of arene radical cations with anions and fluorinated alcohols in hole catalysis

Naoki Shida et al.

COMMUNICATIONS CHEMISTRY (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Green Photo-Organocatalytic C-H Activation of Aldehydes: Selective Hydroacylation of Electron-Deficient Alkenes

Giorgos N. Papadopoulos et al.

CHEMISTRY-A EUROPEAN JOURNAL (2018)

添加到收藏夹

Review Chemistry, Multidisciplinary

Decarboxylative reactions with and without light - a comparison

Johanna Schwarz et al.

GREEN CHEMISTRY (2018)

添加到收藏夹

Review Chemistry, Organic

Photoorganocatalysis, small organic molecules and light in the service of organic synthesis: the awakening of a sleeping giant

Ioanna K. Sideri et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Photoinduced Remote Functionalization of Amides and Amines Using Electrophilic Nitrogen Radicals

Sara P. Morcillo et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

添加到收藏夹

Review Chemistry, Multidisciplinary

Energy transfer catalysis mediated by visible light: principles, applications, directions

Felix Strieth-Kalthoff et al.

CHEMICAL SOCIETY REVIEWS (2018)

添加到收藏夹

Review Multidisciplinary Sciences

Enhancing the potential of enantioselective organocatalysis with light

Mattia Silvi et al.

NATURE (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Multicomponent synthesis of tertiary alkylamines by photocatalytic olefin-hydroaminoalkylation

Aaron Trowbridge et al.

NATURE (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

A Toolbox Approach To Construct Broadly Applicable Metal-Free Catalysts for Photoredox Chemistry: Deliberate Tuning of Redox Potentials and Importance of Halogens in Donor-Acceptor Cyanoarenes

Elisabeth Speckmeier et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Photoorganocatalytic synthesis of lactones via a selective C-H activation-alkylation of alcohols

Nikolaos Kaplaneris et al.

GREEN CHEMISTRY (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Photoredox-catalyzed deuteration and tritiation of pharmaceutical compounds

Yong Yao Loh et al.

SCIENCE (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Photoinduced decarboxylative borylation of carboxylic acids

Alexander Fawcett et al.

SCIENCE (2017)

添加到收藏夹

Review Chemistry, Multidisciplinary

Hexafluoroisopropanol as a highly versatile solvent

Ignacio Colomer et al.

NATURE REVIEWS CHEMISTRY (2017)

添加到收藏夹

Review Chemistry, Multidisciplinary

The merger of transition metal and photocatalysis

Jack Twilton et al.

NATURE REVIEWS CHEMISTRY (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Selective Aerobic Oxidation of Methylarenes to Benzaldehydes Catalyzed by N-Hydroxyphthalimide and Cobalt(II) Acetate in Hexafluoropropan-2-ol

Eden Gaster et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

添加到收藏夹

Review Chemistry, Multidisciplinary

Merging Visible Light Photoredox and Gold Catalysis

Matthew N. Hopkinson et al.

ACCOUNTS OF CHEMICAL RESEARCH (2016)

添加到收藏夹

Review Chemistry, Multidisciplinary

Recent Advances in the Synthesis of Cyclobutanes by Olefin [2+2] Photocycloaddition Reactions

Saner Poplata et al.

CHEMICAL REVIEWS (2016)

添加到收藏夹

Review Chemistry, Multidisciplinary

Applications of Continuous-Flow Photochemistry in Organic Synthesis, Material Science, and Water Treatment

Dario Cambie et al.

CHEMICAL REVIEWS (2016)

添加到收藏夹

Review Chemistry, Multidisciplinary

Organic Photoredox Catalysis

Nathan A. Romero et al.

CHEMICAL REVIEWS (2016)

添加到收藏夹

Review Chemistry, Multidisciplinary

Dual Catalysis Strategies in Photochemical Synthesis

Kazimer L. Skubi et al.

CHEMICAL REVIEWS (2016)

添加到收藏夹

Article Chemistry, Physical

Effects of the charge on the structural, electronic and reactivity properties of 43 substituted N-Phenylmaleimides. A DFT study

Hector F. Cortes Hernandez et al.

JOURNAL OF MOLECULAR STRUCTURE (2016)

添加到收藏夹

Article Chemistry, Applied

A Small-Footprint, High-Capacity Flow Reactor for UV Photochemical Synthesis on the Kilogram Scale

Luke D. Elliott et al.

ORGANIC PROCESS RESEARCH & DEVELOPMENT (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

Characterizing chain processes in visible light photoredox catalysis

Megan A. Cismesia et al.

CHEMICAL SCIENCE (2015)

添加到收藏夹

Article Chemistry, Multidisciplinary

Batch versus Flow Photochemistry: A Revealing Comparison of Yield and Productivity

Luke D. Elliott et al.

CHEMISTRY-A EUROPEAN JOURNAL (2014)

添加到收藏夹

Article Chemistry, Multidisciplinary

Photoorganocatalytic Hydroacylation of Dialkyl Azodicarboxylates by Utilising Activated Ketones as Photocatalysts

Giorgos N. Papadopoulos et al.

CHEMISTRY-A EUROPEAN JOURNAL (2014)

添加到收藏夹

Article Chemistry, Multidisciplinary

Tailoring Atropisomeric Maleimides for Stereospecific [2+2] Photocycloaddition-Photochemical and Photophysical Investigations Leading to Visible-Light Photocatalysis

Elango Kumarasamy et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Reduction of aryl halides by consecutive visible light-induced electron transfer processes

Indrajit Ghosh et al.

SCIENCE (2014)

添加到收藏夹

Article Multidisciplinary Sciences

A Dual-Catalysis Approach to Enantioselective [2+2] Photocycloadditions Using Visible Light

Juana Du et al.

SCIENCE (2014)

添加到收藏夹

Article Chemistry, Organic

Synthetic applications of photoredox catalysis with visible light

Yumeng Xi et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Enantioselective Lewis Acid Catalysis of Intramolecular Enone [2+2] Photocycloaddition Reactions

R. Brimioulle et al.

SCIENCE (2013)

添加到收藏夹

Article Chemistry, Organic

An Efficient Synthesis of (+/-)-Grandisol Featuring 1,5-Enyne Metathesis

Thomas J. A. Graham et al.

JOURNAL OF ORGANIC CHEMISTRY (2010)

添加到收藏夹

Article Chemistry, Organic

Effect of addition of trifluoroacetic acid on the photophysical properties and photoreactions of aromatic imides

Kazuhiko Matsubayashi et al.

TETRAHEDRON (2010)

添加到收藏夹

Article Multidisciplinary Sciences

Synthesis at the molecular frontier

Paul A. Wender et al.

NATURE (2009)

添加到收藏夹

Article Chemistry, Organic

Control of photophysical properties and photoreactions of aromatic imides by use of intermolecular hydrogen bonding

Kazuhiko Matsubayashi et al.

JOURNAL OF ORGANIC CHEMISTRY (2008)

添加到收藏夹

Article Multidisciplinary Sciences

Merging photoredox catalysis with organocatalysis: The direct asymmetric alkylation of aldehydes

David A. Nicewicz et al.

SCIENCE (2008)

添加到收藏夹

Article Chemistry, Organic

A practical flow reactor for continuous organic photochemistry

BDA Hook et al.

JOURNAL OF ORGANIC CHEMISTRY (2005)

添加到收藏夹

Article Chemistry, Physical

Maleimides as electron-transfer photoinitiators: quantum yields of triplet states and radical-ion formation

J von Sonntag et al.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY (2000)

添加到收藏夹

Hexafluoroisopropanol-Promoted or Bronsted Acid-Mediated Photochemical [2+2] Cycloadditions of Alkynes with Maleimides

相关参考文献

导出引文

分享论文