Mechanochemical Synthesis of Polymorphic Urea . Adipic Acid Cocrystal as a Sustained-Release Nitrogen Source

A 2 : 1 urea . adipic acid cocrystal was obtained in two polymorphic forms (Form I reported earlier, and Form II synthesized in this study) using mechanochemistry as well as solution crystallization. Lower solubility and leaching study showed the newly synthesized urea . adipic acid 2 : 1 cocrystal to be an efficient sustained-release nitrogen fertilizer compared to commercially available urea.

Automated summary

A 2:1 urea·adipic acid cocrystal was obtained in two polymorphic forms using mechanochemistry and solution crystallization. The newly synthesized cocrystal exhibited lower solubility and better sustained-release properties compared to commercially available urea.