The Extended Hadamard Transform: Sensitivity-Enhanced NMR Experiments Among Labile and Non-Labile 1Hs of SARS-CoV-2-derived RNAs

Article Chemistry, Multidisciplinary

Magnetization Transfer to Enhance NOE Cross-Peaks among Labile Protons: Applications to Imino-Imino Sequential Walks in SARS-CoV-2-Derived RNAs

Mihajlo Novakovic et al.

Summary: The study introduces an alternative method, Selective Magnetization Transfer (SMT), based on encoding a priori selected peaks by selective saturations, to enhance NOEs between labile sites in RNA, particularly imino-imino cross-peaks. This method plays a crucial role in structural NMR and accelerates the NMR resolution of RNA structures.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

3D Heteronuclear Magnetization Transfers for the Establishment of Secondary Structures in SARS-CoV-2-Derived RNAs

Jihyun Kim et al.

Summary: This study introduces a heteronuclear-resolved version of NOESY experiments, which controls magnetization transfers by selecting specific chemical shift combinations to enhance cross-peaks, greatly facilitating RNA assignments and secondary structure determinations.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Exploring the Druggability of Conserved RNA Regulatory Elements in the SARS-CoV-2 Genome

Sridhar Sreeramulu et al.

Summary: The study identified ligand-binding pockets in RNA elements of SARS-CoV-2 through NMR screening, selecting the most promising ones as potential drug targets. Key functional units and ligand groups for effective targeting of SARS-CoV-2 RNA were derived from the identified hits.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

添加到收藏夹

Article Multidisciplinary Sciences