A Bimetallic Nanozyme with Cascade Effect for Synergistic Therapy of Cancer

Novel nanocomposites were constructed through encapsulation of Au nanoparticles and Ru nanoparticles into dendritic mesoporous silica (DMSN-Au-Ru NPs). These exhibit improved effects due to a cascade catalytic ability for the synergistic therapy of cancer. Au nanoparticles with glucose oxidase-like properties were found to catalyze the oxidation of glucose to produce H2O2, while Ru nanoparticles could decompose H2O2 and produce toxic O-1(2) for improved photodynamic therapy (PDT). In addition, the nanocomposites were found to have good photothermal performance under irradiation by near-infrared (NIR) light. Both in vitro and in vivo experiments show that the nanocomposites have good therapeutic effects due to the cascade catalytic effect and synergistic effect. These findings provide an effective way to design a new generation of nanodrugs for highly efficient cancer treatment.

Automated summary

Novel nanocomposites were constructed by encapsulating Au nanoparticles and Ru nanoparticles into dendritic mesoporous silica. These nanocomposites exhibit cascade catalytic ability and good photothermal performance, showing improved effects through synergistic therapy in cancer treatment.