期刊
CHEMMEDCHEM
卷 17, 期 4, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.202100701
关键词
fluorine-19; magnetic resonance imaging; nanostructures; cancer theranostics; imaging agents
资金
- National Natural Science Foundation of China [81903662, 51903201]
- Natural Science Foundation of Shaanxi Province [2020JQ-086]
- Applied Basic Research Programs of Shanxi Province [201901D211347]
- Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi [2019L0428]
- NIH/NCI Cancer Center Support Grant [P30 CA008748]
Fluorine magnetic resonance imaging (F-19 MRI) is a promising imaging technique for cancer diagnosis, offering excellent resolution and penetration. Scientists have synthesized various fluorinated contrast agents by integrating nanomaterials and construction strategies to enhance the intensity of F-19 MRI signals.
Fluorine magnetic resonance imaging (F-19 MRI) is a promising imaging technique for cancer diagnosis because of its excellent soft tissue resolution and deep tissue penetration, as well as the inherent high natural abundance, almost no endogenous interference, quantitative analysis, and wide chemical shift range of the F-19 nucleus. In recent years, scientists have synthesized various F-19 MRI contrast agents. By further integrating a wide variety of nanomaterials and cutting-edge construction strategies, magnetically equivalent F-19 atoms are super-loaded and maintain satisfactory relaxation efficiency to obtain high-intensity F-19 MRI signals. In this review, the nuclear magnetic resonance principle underlying F-19 MRI is first described. Then, the construction and performance of various fluorinated contrast agents are summarized. Finally, challenges and future prospects regarding the clinical translation of F-19 MRI nanoprobes are considered. This review will provide strategic guidance and panoramic expectations for designing new cancer theranostic regimens and realizing their clinical translation.
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