Understanding the Performance of Metal-Organic Frameworks for Modulation of Nitric Oxide Release from S-Nitrosothiols

S-Nitrosothiols (RSNOs) which are important intermediates in circulating reservoirs of nitric oxide (NO), transport and numerous NO signaling pathways play intricate roles in the etiology of several pathologies. However, it is still a challenge to control the release of NO from nitrosylated compounds under physiological pH. In this paper, for the first time, we report the catalytic activity and kinetic study for the modulation of NO release from RSNOs by an array of metal-organic frameworks (MOFs) (M-MOF (M '); M=Zr, Cu; and M '=Cu, Pd, no metal) under physiological conditions via time-dependent absorbance spectra. The result showed that metal active sites as well as the morphology and pore size of MOFs exhibited different activities toward RSNOs. The order of catalytic activity of these MOFs toward RSNOs is ordered in the decreasing sequence: Cu-MOF(Pd)>Cu-MOF(Cu)>Cu-MOF(no metal)>Zr-MOF(Pd)>Zr-MOF(Cu)>Zr-MOF(no metal). In addition, Zr-MOF(Pd) was as model for cell experiment, demonstrated Zr-MOF(Pd) could react with RSNOs to generate NO in the complex environment of cell. Collectively, these findings establish a platform for MOFs-based, highly catalyze RSNOs in biological samples, a powerful tool for expanding the knowledge of the biology and chemistry of NO-mediated phenomena.

Automated summary

This paper presents the catalytic activity and kinetic study of metal-organic frameworks (MOFs) on the modulation of NO release from RSNOs, showing that different MOFs exhibit varying catalytic activities towards RSNOs, with Cu-MOF(Pd) being the most active. Zr-MOF(Pd) was also demonstrated to have the ability to generate NO from RSNOs in cell experiment, suggesting potential applications in biological samples.