期刊
CHEMISTRY-AN ASIAN JOURNAL
卷 16, 期 24, 页码 4018-4036出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.202101022
关键词
peptide; blood-clotting; sealant; growth factor mimetics; wound healing
资金
- DBT [BT/PR27059/NNT/28/1543/2017]
- IISER Kolkata
- DST INSPIRE
- CSIR
- DST-SERB
Developing non-immunogenic therapeutic biomolecules for facilitating blood clotting followed by wound healing via therapeutic angiogenesis is a formidable challenge. Advancements in stabilized growth-factor-based proangiogenic therapy offer effective possibilities for the treatment of ischemic pathology. Nature-inspired biocompatible stabilized peptide- and protein-based molecular medicines are being explored to address traumatic coagulopathy and impaired wound healing.
Developing non-immunogenic therapeutic biomolecules for facilitating blood clotting followed by wound healing via therapeutic angiogenesis, still remains a formidable challenge. Excessive blood loss of accident victims and battalions cause a huge number of deaths worldwide. Patients with inherited bleeding disorders face acute complications during injury and post-surgery. Biologically-inspired peptide-based hemostat can act as a potential therapeutic for handling coagulopathy. Additionally, non-healing wounds for patients having ischemic diseases can cause severe clinical complications. Advancement in stabilized growth-factor-based proangiogenic therapy may offer effective possibilities for the treatment of ischemic pathology. This review will discuss nature-inspired biocompatible stabilized peptide- and protein-based molecular medicines to serve unmet medical challenges for handling traumatic coagulopathy and impaired wound healing.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据