期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 28, 期 11, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202103903
关键词
base-metal catalysis; cobalt; etherification; hydrogenation; phosphine oxides
资金
- CNPq (Brazil)
- FAPEMIG (Brazil)
- INCT-Catalise (Brazil)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [001 (88887.364603/2019-00)]
- State of Mecklenburg-Western Pomerania
A phosphine-oxide-promoted, cobalt-catalysed reductive etherification using syngas as a reductant has been reported in this study. This novel methodology has been successfully applied to prepare unsymmetrical ethers from a wide range of aldehydes and alcohols containing diverse functional groups, and the reaction has been scaled-up to multigram scale under relatively mild conditions. Mechanistic experiments suggest an acetalization-hydrogenation sequence.
A phosphine-oxide-promoted, cobalt-catalysed reductive etherification using syngas as a reductant is reported. This novel methodology was successfully used to prepare a broad range of unsymmetrical ethers from various aldehydes and alcohols containing diverse functional groups, and was scaled-up to multigram scale under comparably mild conditions. Mechanistic experiments support an acetalization-hydrogenation sequence.
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