期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 28, 期 6, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202103642
关键词
benzimidazole derivatives; cell imaging; Cu (II) sensor; fluorescent probe; mesoporous silica
资金
- National Natural Science Foundation of China [22005160]
- National Key Research and Development Program of China [2019YFC1604600, 2017YFA0206901]
- major scientific and technological innovation projects of Shandong Province [2018CXGC1406]
- Qilu University of Technology (Shandong Academy of Sciences) Science, Education and Industry integration innovation pilot Project [2020KJC-ZD07]
Mesoporous silica nanoparticles (MSNs) functionalized with benzimidazole-derived fluorescent molecules (DHBM) were utilized for highly sensitive and selective detection of Cu2+ through a feasible interfacial superassembly strategy, showing a quenching effect on Cu2+ in aqueous solutions with a detection limit as low as 7.69x10(-8) M. The solid-state sensor demonstrated good recyclability, and the silica framework enhanced the photostability of DHBM. These findings suggest that the DHBM-MSN fluorescent sensor has great potential for practical and biomedical applications.
Mesoporous silica nanoparticles (MSNs) functionalized with benzimidazole-derived fluorescent molecules (DHBM) are fabricated via a feasible interfacial superassembly strategy for the highly sensitive and selective detection of Cu2+. DHBM-MSN exhibits an obvious quenching effect on Cu2+ in aqueous solutions, and the detection limit can be as low as 7.69x10(-8) M. The DHBM-MSN solid-state sensor has good recyclability, and the silica framework can simultaneously improve the photostability of DHBM. Two mesoporous silica nanoparticles with different morphologies were specially designed to verify that nanocarriers with different morphologies do not affect the specific detectionability. The detection mechanism of the fluorescent probe was systematically elucidated by combining experimental results and density function theory calculations. Moreover, the detection system was successfully applied to detect Cu2+ in bovine serum, juice, and live cells. These results indicate that the DHBM-MSN fluorescent sensor holds great potential in practical and biomedical applications.
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