期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 28, 期 7, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202103130
关键词
Ab initio calculations; C-C coupling; coinage-metal complexes; kinetics; mass spectrometry
资金
- Deutsche Forschungsgemeinschaft [389479699/GRK2455, KO2875/121, EXC 2033 -390677874 RESOLV]
- Ministry of Innovation, Science and Research of North Rhine-Westphalia (NRW Ruckkehrerprogramm)
- Humboldt foundation
- Projekt DEAL
High-valent tetraalkylcuprates(III) and -argentates(III) are key intermediates in copper- and silver-mediated C-C coupling reactions. Through experiments and calculations, it was found that copper complexes predominantly undergo homo-coupling reactions, while silver complexes primarily undergo cross-coupling reactions. The outer-sphere mechanism was proposed to explain the observed cross-coupling reaction of the silver complex.
High-valent tetraalkylcuprates(III) and -argentates(III) are key intermediates of copper- and silver-mediated C-C coupling reactions. Here, we investigate the previously reported contrasting reactivity of [(RMMe3)-Me-III](-) complexes (M=Cu, Ag and R=allyl) with energy-dependent collision-induced dissociation experiments, advanced quantum-chemical calculations and kinetic computations. The gas-phase fragmentation experiments confirmed the preferred formation of the [RCuMe](-) anion upon collisional activation of the cuprate(III) species, consistent with a homo-coupling reaction, whereas the silver analogue primarily yielded [AgMe2](-), consistent with a cross-coupling reaction. For both complexes, density functional theory calculations identified one mechanism for homo coupling and four different ones for cross coupling. Of these pathways, an unprecedented concerted outer-sphere cross coupling is of particular interest, because it can explain the formation of [AgMe2](-) from the argentate(III) species. Remarkably, the different C-C coupling propensities of the two [(RMMe3)-Me-III](-) complexes become only apparent when properly accounting for the multi-configurational character of the wave function for the key transition state of [RAgMe3](-). Backed by the obtained detailed mechanistic insight for the gas-phase reactions, we propose that the previously observed cross-coupling reaction of the silver complex in solution proceeds via the outer-sphere mechanism.
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