期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 28, 期 11, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202103972
关键词
hydrazones; peptidomimetics; photoisomerization; photoswitches; substituent effects
资金
- National Research Foundation of Korea (NRF) - Korean government (Ministry of Science and ICT) [2020R1C1C1011134]
- Chung-Ang University Graduate Research Scholarship in 2020
- National Research Foundation of Korea [2020R1C1C1011134] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
This study investigates the photomodulation of short peptides by a novel hydrazone switch, demonstrating its potential for controlling biomolecules.
Molecules that undergo light-driven structural transformations constitute the core components in photoswitchable molecular systems and materials. Among various families of photoswitches, photochromic hydrazones have recently emerged as a novel class of photoswitches with superb properties, such as high photochemical conversion, spectral tunability, thermal stability, and fatigue resistance. Hydrazone photoswitches have been adopted in various adaptive materials at different length scales, however, their utilization for modulating biomolecules still has not been explored. Herein, we present new hydrazone switches that can photomodulate the structures of short peptides. Systematic investigation on a set of hydrazone derivatives revealed that installation of the amide group does not significantly alter the photoswitching behaviors. Importantly, a hydrazone switch comprising an upper phenyl ring and a lower quinolinyl ring was effective for structural control of peptides. We anticipate that this work, as a new milestone in the research of hydrazone switches, will open a new avenue for structural and functional control of biomolecules.
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