4.6 Article

Acid-Catalyzed RNA-Oligomerization from 3',5'-cGMP

期刊

CHEMISTRY-A EUROPEAN JOURNAL
卷 27, 期 70, 页码 17581-17585

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202103672

关键词

cGMP; nonenzymatic polymerization; nucleotides; prebiotic chemistry

资金

  1. European Research Council [787356]
  2. Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [364653263]
  3. Projekt DEAL
  4. European Research Council (ERC) [787356] Funding Source: European Research Council (ERC)

向作者/读者索取更多资源

The study demonstrates that the dry polymerization of 3',5'-cyclic guanosine monophosphate (3',5'-cGMP) is not sensitive to the presence of cations when conducted in an acidic environment, contrary to previous reports suggesting optimal conditions at pH 9.
The assembly of ancient informational polymers from nucleotide precursors is the central challenge of life's origin on our planet. Among the possible solutions, dry polymerization of 3',5'-cyclic guanosine monophosphate (3',5'-cGMP) has been proposed as a candidate to create oligonucleotides of 15-20 units in length. However, the reported sensitivity of the reaction to the presence of cations raised questions of whether this chemistry could be relevant in a geological context. The experiments in this study show that the presence of cations is not restrictive as long as the reaction is conducted in an acidic environment, in contrast to previous reports that suggested optimal conditions at pH 9.

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