Two New Cytotoxic Decalin Derivatives from Marine-Derived Fungus Talaromyces sp.

Two new decalin derivatives named fusarielins O (1) and P (2), together with seven known compounds (3-9) were isolated from the crude extract of the marine-derived fungus Talaromyces sp. The planar structures of the new compounds were elucidated by comprehensive spectroscopic analyses of NMR and HR-ESI-MS. The absolute configuration of 1 was assigned by Snatzke's method and comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Compounds 1-9 were evaluated for their cytotoxic activities against three tumor cell lines and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities.

Automated summary

Two new decalin derivatives, fusarielins O and P, were isolated from the crude extract of Talaromyces sp., along with seven known compounds. The structures of the new compounds were determined through comprehensive spectroscopic analyses. The compounds were evaluated for their cytotoxic and radical scavenging activities.