期刊
CHEMISTRY & BIODIVERSITY
卷 19, 期 1, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.202100584
关键词
domino reaction; pyrrolo[2; 1-a]isoquinolines; three-component reactions; CH-acids; terminal alkynes
资金
- Russian Science Foundation [18-73-10099]
- RUDN University Strategic Academic Leadership Program
- Russian Science Foundation [18-73-10099] Funding Source: Russian Science Foundation
A novel synthetic method for obtaining highly functionalized compounds with potentially biologically active pharmacophore groups was developed through a three-component domino reaction of 1-aroyl-3,4-dihydroisoquinolines, terminal alkynes, and CH-acids under microwave irradiation in dry acetonitrile.
Synthesis of novel C3-substituted 5,6-dihydropyrrolo[2,1-a]isoquinolines via a three-component domino reaction of 1-aroyl-3,4-dihydroisoquinolines, terminal alkynes and CH-acids under microwave irradiation in dry acetonitrile is described. The method developed enables the obtainment of highly functionalized compounds with pharmacophore groups, which are potentially biologically active.
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