Copper-catalyzed radical relay in C(sp3)-H functionalization

Radical-involved transition metal (TM) catalysis has greatly enabled new reactivities in recent decades. Copper-catalyzed radical relay offers enormous potential in C(sp(3))-H functionalization which combines the unique regioselectivity of hydrogen atom transfer (HAT) and the versatility of copper-catalyzed cross-coupling. More importantly, significant progress has been achieved in asymmetric C-H functionalization through judicious ligand design. This tutorial review will highlight the recent advances in this rapidly growing area, and we hope this survey will inspire future strategic developments for selective C(sp(3))-H functionalization.

Automated summary

Radical-involved transition metal catalysis enables new reactivities, and copper-catalyzed radical relay shows great potential in C(sp(3))-H functionalization. Significant progress has been made in asymmetric C-H functionalization through ligand design.