期刊
CHEMICAL REVIEWS
卷 122, 期 1, 页码 209-268出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemrev.1c00553
关键词
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资金
- National Key R&D Program of China [2020YFA0908800]
- NSFC [81773674, 82111530209, 21763002, 81973569]
- Shenzhen Science a n d Te c h n o l o g y R e s e a r c h Gr a n t (G r a n t) [JCYJ20190808152019182]
- Hubei Province Scientific and Technical Innovation Key Project [2020BAB058]
- Applied Basic Research Program of Wuhan Municipal Bureau of Science and Technology [2019020701011429]
- Local Development Funds of Science and Technology Department of Tibet [XZ202102YD0033C, XZ202001YD0028C]
- Tibet Autonomous Region Science and Technology Plan Project Key Project [XZ201901-GB-11]
- Chengdu University of Traditional Chinese Medicine [CZYJC1903]
- Fundamental Research Funds for the Central Universities [ZNJC201931]
- National Research Foundation of Korea [2018R1A3B1052702, 2019M3E5D1A01068998]
- Basic Science Research Program [2020R1A6A3A01100558]
- National Research Foundation of Korea [2020R1A6A3A01100558, 4120200213669] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
In vivo imaging in the second near-infrared window (NIR-II) has provided great opportunities for biomedical research and clinical applications. This review summarizes the design, properties, molecular imaging, and theranostics of inorganic/organic NIR-IIa/IIb fluorophores. The versatile applications and imaging modalities enabled by these advanced fluorescent properties are discussed, along with the challenges and perspectives for future clinical translation to boost the progress of NIR-IIa and NIR-IIb imaging technology.
In vivo imaging in the second near-infrared window (NIR-II, 1000-1700 nm), which enables us to look deeply into living subjects, is producing marvelous opportunities for biomedical research and clinical applications. Very recently, there has been an upsurge of interdisciplinary studies focusing on developing versatile types of inorganic/ organic fluorophores that can be used for noninvasive NIR-IIa/IIb imaging (NIR-IIa, 1300-1400 nm; NIR-IIb, 1500-1700 nm) with near-zero tissue autofluorescence and deeper tissue penetration. This review provides an overview of the reports published to date on the design, properties, molecular imaging, and theranostics of inorganic/organic NIR-IIa/IIb fluorophores. First, we summarize the design concepts of the up-to-date functional NIR-IIa/IIb biomaterials, in the order of single-walled carbon nanotubes (SWCNTs), quantum dots (QDs), rare-earth-doped nanoparticles (RENPs), and organic fluorophores (OFs). Then, these novel imaging modalities and versatile biomedical applications brought by these superior fluorescent properties are reviewed. Finally, challenges and perspectives for future clinical translation, aiming at boosting the clinical application progress of NIR-IIa and NIR-IIb imaging technology are highlighted.
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