Magnetic-Optical Imaging for Monitoring Chemodynamic Therapy

Chemodynamic therapy kills cancer cells with reactive oxygen species generated by endogenous triggers in the tumor microenvironment. Although chemodynamic therapy is blossoming in recent years, their therapy process still faces a series of hampers. The unknown catalytic activity of chemodynamic therapy reagents may lead to unpredictable therapy effects, so it is necessary to reveal the therapeutic mechanism of chemodynamic therapy and develop self-monitoring probes. In this mini-review, we summarize and illustrate the most recent progress of chemodynamic therapy, focusing on the applications of magnetic imaging and optical imaging probe for monitoring cancer chemodynamic therapy. Furthermore, we also discuss the potential challenges and the further directions of this field.

Automated summary

Chemodynamic therapy utilizes reactive oxygen species generated by endogenous triggers in the tumor microenvironment to kill cancer cells. Despite the recent progress in this field, challenges such as unknown catalytic activity of therapy reagents and unpredictable treatment effects still exist. It is necessary to reveal the therapeutic mechanism of chemodynamic therapy and develop self-monitoring probes to address these challenges.