期刊
CHEMICAL ENGINEERING JOURNAL
卷 425, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2021.130579
关键词
Iron oxide nanoparticles; Nanozyme; Magnetic Resonance Imaging; Near-infrared Fluorescence Imaging; Immunotherapy
资金
- National Natural Science Foundation of China [NSFC 8174100199, 81971607, 81471778]
- Key Areas Research and Development Program of Guangdong [2019B020235001]
- Science and Technology Program of Guangzhou [201804010101]
- Science and Technology Project of Yantian District in Shenzhen City, Guangdong Province, China [20190106]
- Sun Yat-sen University Young Teacher Training Project [20lgpy07]
- Guangdong Provincial Basic and Applied Basic Research Fund, Natural Science Foundation of Guangdong Province, China [2021A1515011799]
Triple-negative breast cancer lacks sufficient biomarkers to guide the benefits of immunotherapy; a theranostic nanocomposite with dual imaging modality and chemical phototherapeutic capacity has been developed for breast cancer cell inhibition, promoting imaging-guided phototherapy.
Triple-negative breast cancer has few biomarkers to guide benefit from immunotherapy; furthermore, the biochemical features of the tumor microenvironment including acidosis, hypoxia, and high hydrogen peroxide concentrations, significantly modulate cancer cell metabolism and metastatic potential, and associate with bad outcomes from chemo-radiotherapy and surgery. Herein, a theranostic nanocomposite with a dual imaging modality and chemical phototherapeutic capacity has been used for breast cancer cell inhibition, which is developed to self-assemble superparamagnetic iron oxide nanocrystals and IR-780 iodides in one system. Due to the magnetic resonance and near-infrared II fluorescence capacity, this nanocomposite serves as a contrast agent for the high-sensitivity, accurate cancer diagnosis and facilitates imaging-guided phototherapy. Furthermore, this nanocomposite not only performs dual enzyme-like activities in the tumor microenvironment, but also carries out the bioeffect of hyperthermia and oxidative stress, which could repolarize tumor-associated macrophages from the tumor-promoting M2 phenotype into the tumoricidal M1 phenotype, reduce the number of immunosuppressive cells, and execute immune activation. Through simultaneous chemical phototherapy and anti-tumor immunity, this iron oxide-based nanocomposite successfully suppresses tumor growth and metastasis, and has good biocompatibility in normal tissues and organs; thus, it might provide new insights into the development of a novel cancer therapy strategy.
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