期刊
CHEMICAL ENGINEERING JOURNAL
卷 426, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2021.130827
关键词
Hemisection spinal cord injury; Hydrogel; Self-adhesion; Dental pulp stem cell; Fibroblast growth factor 21; Cadherin
资金
- National Natural Science Funding of China [81802235]
- Zhejiang Medical and Health Science and Technology Plan Project [2021KY212]
- Wenzhou Basic Science Research Plan Project [Y2020050]
- CAMS Innovation Fund for Medical Sciences [2019-I2M-5-028]
A hydrogel containing calcium alginate, DPSCs, and FGF21 was designed to improve recovery after spinal cord hemisection by regulating apoptosis and autophagy in mice.
Spinal cord injury (SCI) often leads to persistent functional deficits due to loss of neurons and glia after injury. Hemisection spinal cord injury (HSCI) is a special type of SCI. The most important difference between HSCI and SCI is the occurrence of spinal cord dissection. Therefore, a calcium alginate hydrogel combined with dental pulp stem cells (DPSCs) and fibroblast growth factor 21 (FGF21) was designed based on the principle that cadherin expression is regulated by calcium ion concentration. Each element in Ca2+@Alg-FGF21 + DPSC hydrogel can exert different effects 1). calcium ions can regulate cadherin to achieve self-adhesion; 2). alginic acid can absorb calcium ions to prevent calcium overload induced injury; 3) FGF21 can regulate microenvironment; 4). DPSCs can supplement exogenous neurons. The multi-factorially comprehensive effects were hypothesized to improve the HSCI recovery. It was revealed in our study that Ca2+@Alg-FGF21 + DPSC hydrogel could effectively promote the recovery after spinal cord hemisection in mice via regulating apoptosis and autophagy, providing potential clues and cues of using Ca2+@Alg-FGF21 + DPSC hydrogel for HSCI treatment.
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