期刊
CHEMICAL ENGINEERING JOURNAL
卷 421, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2021.130005
关键词
Tannic acid; Antifouling; Antibacterial; Photothermal; Gold nanoparticles
资金
- National Key RAMP
- D Program of China [2017YFC1600900]
- National Natural Science Foundation of China [21504072, 51741304, 52073234]
- Natural Science Foundation of Chongqing [cstc2019jcyjmsxmX0363]
- Innovation Teams in Colleges and Universities of Chongqing [CXQT20005]
- Chongqing Engineering Research Center for MicroNano Biomedical Materials and Devices
This study developed a novel biomaterial for medical devices with excellent antibacterial and antifouling properties, providing an effective strategy to combat medical device-associated infections.
Severe medical device-associated infections caused by pathogenic bacteria have become an immediate threat to global public health, mainly because of the development of multiple drug resistance (MDR). Relevant design of functionalized biomaterials are thus essential to remit or mitigate the medical device-associated infections. In the present work, we developed a strategy of combining antifouling and photothermal therapy (PTT) in a single platform for antibacterial applications. The polydimethylsiloxane (PDMS) surface was modified with poly (ethylene glycol) (PEG) and tannic acid-reduced gold nanoparticles (Au@TA NPs) for better photothermal and antifouling performance. PEG facilitates the rapid self-assembly of Au@TA NPs on the surface to form a stable Au@TA NPs/PEG (TA-PEG-Au) layer. The functionalized surface with antifouling and antibacterial properties arise from the inherent fouling resistance of PEG and photothermal conversion of Au NPs. The TA-PEG-Au coating exhibits remarkable antifouling performance to bacterial adhesion and excellent antibacterial property under near-infrared (NIR) irradiation both in vitro and in vivo. The antibacterial TA-PEG-Au coatings also show low cytotoxicity. The present work provides an efficient strategy for the design of high-performance antifouling and antibacterial materials to fight against medical device-associated infections.
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