期刊
CHEMICAL ENGINEERING JOURNAL
卷 429, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2021.132328
关键词
Cancer therapy; Nanomaterial; Radiation therapy; Radiosensitization; Nitric monoxide
Nano-radiosensitization is a new concept for cancer therapy that enhances radiosensitization using nanomaterials. In this study, a novel strategy was described, which involved the release of anticancer nitric oxide (NO) by irradiation-triggered switching of a nanoprodrug. This strategy improved tumor hypoxia and generated reactive oxygen species (ROS) to effectively kill cancer cells.
Nano-radiosensitization is an emerging concept for cancer therapy and the underlying rationale embroils enhancement of radiosensitization by nanomaterials. Here we describe a new concept of the irradiation-triggered switching of a biologically inert nano-prodrug to releasing an anticancer gas that executes cancer cells killing and improves radiosensitization by improving the tumor hypoxic microenvironment. This novel strategy employed chemical coordination between radiosensitive gold-coated polyethylene glycol (PEG) nanoparticles and nanoclusters (AuNCs-PEG) and sodium nitroprusside (SNP) coated by platelet membranes (PM) to generate AuNCs-PEG-SNP-PM (APS), which upon irradiation released a high content of anticancer nitric oxide (NO) through a reaction of SNP and L-glutathione (GSH). NO inhibited cell respiration and O-2 consumption through the downregulation of hypoxia inducible factor-1 alpha (HIF-1 alpha). Consequently, O-2 accumulation improved therapeutic outcomes by generating ROS in the tumor microenvironment. In preclinical cancer models, we showed that this approach nearly completely eradicated tumors without producing any notable adverse effects. Our therapeutic strategy may provide a new paradigm for effective treatment of various types of cancers.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据