期刊
CHEMICAL ENGINEERING JOURNAL
卷 421, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2021.129761
关键词
Near-infrared luminophores; Electrochemiluminescence; Porphyrin dots; Biosensor; Lead ion
资金
- National Natural Science Foundation of China [21272188, 22077105]
- Natural Science Foundation Project of CQ CSTC [cstc2020jcyj-msxmX0854]
The study demonstrates the excellent performance and stability of three types of porphyrin dots in electrochemiluminescence, with significantly higher ECL efficiency in the S2O82- cathodic system compared to the standard. Additionally, a biosensor utilizing these porphyrin dots shows ultrasensitive detection of Pb2+.
Exploring novel near-infrared (NIR) luminophore with highly efficient and benign is strongly anticipated for electrochemiluminescence (ECL) evolution. Here, three kinds of porphyrin dots including 5,10,15,20-tetrakis (4carboxyphenyl) porphyrin (TCPP) dots, ZnTCPP dots and TCPP-based metal organic framework (pMOF) dots have been subtly synthesized for the first time by a universal straightforward exfoliation of bulk porphyrin aggregates or pMOF. These as-designed porphyrin dots perform excellent annihilation ECL activity, also exhibit stable and robust cathodic or anodic NIR ECL properties with different coreactants (potassium peroxydisulfate, hydrogen peroxide or tri-n-propylamine) in aqueous phase. Especially, the ECL efficiency of three kinds of porphyrin dots in S2O82- cathodic system are 56, 44, 39-fold higher than that of the Ru(bpy)32+ standard, respectively. As a new type of ECL luminophores, TCPP dots coupled with a lead ion-dependent DNAzyme and hybridization chain reaction cycle amplification are used to fabricate a label free signal-on ECL biosensor for ultrasensitive detection of Pb2+. A dynamic range from 10 pmol center dot L-1 to 1 mu mol center dot L- 1 with a low limit of detection (1.2 pmol center dot L-1) is obtained. These porphyrin dots provide evidence for the use of organics-based dots as new NIR ECL luminophores for fundamental ECL research, and highlight the significance of small-sized organic nanomaterials in ECL sensing applications.
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