期刊
CHEMICAL ENGINEERING JOURNAL
卷 437, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2022.135304
关键词
Boron nitride nanosheet; Salt-template; CPT; Drug delivery
资金
- National Nature Science of China [21903021]
- Innovation Platform and Talent Plan of Hunan Province [2019RS1027]
- Fundamental Research Funds for the Central Universities (Hunan University) [531119200114]
This study develops an efficient drug nanocarrier that can improve the efficacy of chemotherapy, reduce side effects and drug resistance. Pure and crystalline boron nitride nanosheets (BNNSs) were successfully synthesized using a new method and shown to have good dispersibility and stability in water. Experiments demonstrate that these nanosheets can effectively deliver anticancer drugs and inhibit the growth of breast cancer.
Development of advanced drug nanocarriers that can improve cancer chemotherapeutic efficacy, reduce side effect and drug resistance is of particular interests. In this work, pure and crystalline boron nitride nanosheets (BNNSs) were synthesized by a NaCl-template reaction with the yield over 1 g for a single reaction, which is 1-3 orders of magnitudes higher than other common lab-based techniques, such as liquid exfoliation, ball milling, etc. After hydroxylation, the OH-BNNSs showed high dispersibility in water and stability for over two days without precipitation at a concentration of 1 mg mL(-1). When applied for CPT delivery, the highly biocompatible OH-BNNSs could effectively load and deliver CPT for effective 4T1 breast cancer inhibitions both in vitro and in vivo, suggesting the potentials of the BNNSs for drug delivery applications. This work provides an efficient and practical way for large-scale productions of BNNSs for biomedical applications.
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