期刊
CHEMICAL ENGINEERING JOURNAL
卷 430, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2021.132898
关键词
Black phosphorus nanosheets; Starvation therapy; Nitric oxide; Photothermal therapy; Synergistic therapy
资金
- Fundamental Research Funds for the Central Universities [2632020ZD13]
- National Natural Science Foundation of China [NSFC 31800154, 51903088]
- China Postdoctoral Science Foundation [2021M693953]
- Jiangsu Province Postdoctoral Science Foundation [2021K385C]
- Natural Science Foundation of Jiangsu Province [BK20211221]
A novel GBM treatment strategy combining photothermal therapy, tumor starvation, and nitric oxide therapy is developed using functionalized black phosphorus nanosheets. The mild chemical modification empowers BP with superior stability and induces release of H2O2 and NO. Membrane-coated BPAG shows improved penetration and GBM targeting ability.
Glioblastoma (GBM) is the most common type of primary malignant brain tumor with few innovative therapies. Developing an efficient and green synergistic anticancer strategy for GBM treatment remains a pressing need. Herein, a novel strategy that combines photothermal therapy (PTT), tumor starvation and nitric oxide (NO) therapy based on functionalized black phosphorus nanosheets (BP) is developed. NO-functionalized BP (BPA) is prepared by esterification reaction between the carboxyl group of L-arginine (Arg) and the hydroxyl group (P OH) formed from the preliminary oxidation on the surface of BP. Then glucose oxidase (GOx) is further introduced to Arg by amidation to form a multimodal nanodrug (BPAG). The mild chemical modification empowers BP with superior stability under physiological condition and induce release of H2O2 and NO by the cascaded oxidation of glucose and Arg. This process can be significantly accelerated by PTT. To facilitate BPAG with tumor-targeting ability, the macrophage membrane is used to coat the nanoparticles under ultrasonic condition. The membrane-coated BPAG (M@BPAG) improves penetration through blood-brain barrier for GBM targeting. Taken together, M@BPAG combines GBM targeting, H2O2-NO release, and PTT effect, leading to reprogramming the tumor immune microenvironment and a significant synergistic antitumor performance without systemic toxicity.
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