Pd/Cu bimetallic catalysis to access highly fluorinated biaryls from aryl halides and fluorinated arenes

An efficient Pd/Cu bimetallic cross-coupling catalysis of fluoroaryl halides and fluoroarenes is reported. In situ generation of the Cu nucleophile by rate determining C-H activation of highly fluorinated aryls (>= 4 F atoms) leads to high cross-coupling selectivity with little formation of homocoupling products.

Automated summary

An efficient Pd/Cu bimetallic cross-coupling catalysis for fluoroaryl halides and fluoroarenes is reported. The in situ generation of Cu nucleophile through rate-determining C-H activation of highly fluorinated aryls (>=4 F atoms) leads to high selectivity in cross-coupling reactions with minimal formation of homocoupling products.