Photoredox catalyzed cascade CF3 addition/chemodivergent annulations of ortho-alkenyl aryl ureas

Herein, we report a substrate-controlled cascade cyclization of o-alkenyl aryl ureas, an ambident nucleophile for constructing functionalized heterocycles such as 2-amino-1,3-benzoxazines and dihydroquinazolinones in a chemodivergent fashion using photoredox catalysis under mild conditions. The versatility of the method has been successfully demonstrated by applying this strategy to a wide range of substrates and for the synthesis of functionalized etifoxine drug derivatives.

Automated summary

We report a substrate-controlled cascade cyclization method for constructing functionalized heterocycles using photoredox catalysis under mild conditions. This versatile method has been successfully applied to a wide range of substrates and for the synthesis of functionalized etifoxine drug derivatives.