A tri-modal paper device based on flower-like CuSe for the detection of an Alzheimer's disease-associated microRNA marker

A tri-modal paper device based on flower-like CuSe was developed for monitoring Alzheimer's disease (AD)-related miRNA by integrating colorimetric, photothermal and surface-enhanced Raman scattering approaches. Significantly, false-negative signals at the early stage of AD were completely eliminated by using our presented tri-modal strategy.

Automated summary

A tri-modal paper device based on flower-like CuSe was developed for monitoring Alzheimer's disease-related miRNA by integrating colorimetric, photothermal, and surface-enhanced Raman scattering approaches. The presented tri-modal strategy effectively eliminates false-negative signals at the early stage of Alzheimer's disease.