Silver-catalyzed monofluoroalkylation of heteroarenes with α-fluorocarboxylic acids: an insight into the solvent effect

A mild and efficient method for direct C-H monofluoroalkylation of heteroarenes with easily accessible and inexpensive alpha-fluorocarboxylic acids has been developed. This silver-catalyzed reaction affords mono- and bis-monofluoroalkylated heteroarenes in good yields under mild conditions, and the solvent effect on the monofluoroalkylation reaction is discussed in detail.

Automated summary

A mild and efficient method for direct C-H monofluoroalkylation of heteroarenes using easily accessible and inexpensive alpha-fluorocarboxylic acids has been developed. This silver-catalyzed reaction yields mono- and bis-monofluoroalkylated heteroarenes in good yields under mild conditions, with detailed discussion on the solvent effect on the monofluoroalkylation reaction.