Three-component addition of terminal alkynes, carboxylic acids, and tert-butyl hypochlorite

This paper described the unprecedented three-component addition of terminal alkynes, carboxylic acids, and tert-butyl hypochlorite. This new type of addition proceeds smoothly to produce gem-dichloroalkane derivatives in satisfactory to excellent yields via successive two-time additions under mild conditions. The synthetically useful functional groups, such as Cl, Br, CN, and NO2, remained intact in the final products.

Automated summary

This paper describes an unprecedented three-component addition reaction, which allows for the efficient synthesis of gem-dichloroalkane derivatives in mild conditions without affecting important functional groups.