Photoredox catalyzed C-H trifluoroethylamination of heteroarenes

The first C-H trifluoroethylamination of heteroarenes with previously unknown N-trifluoroethyl hydroxylamine reagents was achieved under photoredox catalyzed conditions. In the presence of an iridium(iii) photoredox catalyst, a variety of heteroarenes, such as indoles, benzofurans, and benzothiophenes, were smoothly converted to the trifluoroethylaminated products in moderate to high yields and with excellent regioselectivity.

Automated summary

The first C-H trifluoroethylamination of heteroarenes using previously unknown N-trifluoroethyl hydroxylamine reagents was achieved under photoredox catalyzed conditions. Various heteroarenes, such as indoles, benzofurans, and benzothiophenes, were smoothly converted to trifluoroethylaminated products with moderate to high yields and excellent regioselectivity.