Metal-free synthesis of β-aminoketones by the reductive hydroamination of ynones

This study describes a cascade method for the synthesis of beta-aminoketones through the reductive hydroamination of alkynes under very mild metal-free conditions. It allows for the rapid conversion of ynones and amines into corresponding beta-aminoketones with a broad substrate scope and diverse functionalities. This straightforward and easy-to-handle reaction process can be successfully applied for the synthesis of Proroxan and Propipocaine, offering a potential option for the synthesis of drug molecules with the beta-aminoketone skeleton.

Automated summary

This study presents a cascade method for the synthesis of beta-aminoketones through the reductive hydroamination of alkynes under mild metal-free conditions. The method offers a rapid and diverse approach for the synthesis of drug molecules with the beta-aminoketone skeleton.