Synthesis of a novel chiral DA-TD covalent organic framework for open-tubular capillary electrochromatography enantioseparation

Herein, a novel chiral covalent organic framework, DA-TD COF, with good chemical/thermal stability was synthesized and used as a chiral stationary phase for open-tubular capillary electrochromatography enantioseparation. The DA-TD COF coated capillary exhibited excellent enantioseparation efficiency and its separation efficiency did not show an obvious decrease over 200 runs. Furthermore, the enantioseparation mechanism was studied.

Automated summary

A novel chiral COF, DA-TD COF, was synthesized and used as a chiral stationary phase for open-tubular capillary electrochromatography, showing excellent enantioseparation efficiency and stability. The enantioseparation mechanism was also studied in this work.