期刊
CHEMICAL COMMUNICATIONS
卷 58, 期 2, 页码 242-245出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc05823a
关键词
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资金
- JSPS KAKENHI [JP19H02724, JP20J12227]
- JST CREST [JPMJCR20R3]
- Keio University Academic Development Funds
- Keio Gijuku Fukuzawa Memorial Fund for the Advancement of Education and Research
A novel tumor-related biomarker, a H2O2-activatable photosensitizer 4 based on hypocrellin B (3), was synthesized. Photosensitizer 4 showed selective and effective photo-cytotoxicity against high H2O2-expressing cancer cells under 660 nm light irradiation, demonstrating potential for targeted cancer therapy.
A novel tumor-related biomarker, a H2O2-activatable photosensitizer 4 based on the 1,3-dicarbonyl enol moieties of hypocrellin B (3), was designed and synthesized. The photosensitizer 4 showed a blue-shifted absorption band compared with 3, and showed negligible photosensitizing ability without H2O2. However, the release of 3 from 4 by the reaction with H2O2 regenerated the photosensitizing ability. Furthermore, 4 exhibited selective and effective photo-cytotoxicity against high H2O2-expressing cancer cells upon photo-irradiation with 660 nm light, which is inside the phototherapeutic window.
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