期刊
CHEMICAL COMMUNICATIONS
卷 58, 期 20, 页码 3338-3341出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cc00159d
关键词
-
资金
- National Natural Science Foundation of China [21772157]
- Project of Science and Technology of Social Development in Shaanxi Province [2021SF-120]
A glycol nanomedicine utilizing a metal-coordination supramolecular self-assembly strategy was developed, which demonstrated successful drug target delivery and release monitoring. Enhanced anti-cancer efficiency was achieved through synergistic therapy of chemotherapy and chemodynamic therapy. This technology may have significant applications in drug tracking and combined cancer therapy.
A glycol nanomedicine based on a metal-coordination supramolecular self-assembly strategy of GluCC (a copper complex of glucose modified coumarin derivative) and a chemotherapeutic agent of doxorubicin (DOX) was successfully developed. In vitro studies revealed that the nanomedicine achieved drug target delivery and release monitoring. The anti-cancer efficiency could be enhanced through synergistic therapy of chemotherapy (CT) and chemodynamic therapy (CDT). It may gain important applications in drug tracking and CDT-combined cancer therapy.
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