期刊
CHEMCATCHEM
卷 14, 期 8, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cctc.202200136
关键词
asymmetric synthesis; indoles; organocatalysis; Steglich rearrangement; zwitterions
资金
- Research Grants Council of the Hong Kong Special Administration Region [CUHK14305520]
- Chinese University of Hong Kong Direct Grant [4053394]
- Innovation and Technology Commission [GHP/004/16GD]
A class of cinchona alkaloid-derived zwitterions has been successfully used to achieve highly enantioselective Steglich rearrangement and the same catalytic protocol was found applicable in the asymmetric aldol reaction. Studies were conducted to elucidate a clearer mechanism.
A class of cinchona alkaloid-derived zwitterions has been successfully applied to achieve highly enantioselective Steglich rearrangement. A series of O-acylated oxindoles afforded C-acylated oxindoles possessing a quaternary stereocenter. These products were obtained in high yields and with excellent enantioselectivity. The same catalytic protocol was also found to be applicable in the asymmetric aldol reaction of oxindoles. Studies were conducted to elucidate a clearer mechanism. These findings will advance the development of new reaction protocols that exploit cinchona alkaloid-derived zwitterions as asymmetric nucleophilic catalysts.
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