期刊
CHEMBIOCHEM
卷 23, 期 5, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.202100655
关键词
analytical methods; ct(6)A; hydantoin synthesis; ms(2)ct(6)A; tRNA modified nucleosides
资金
- National Science Center, Poland [UMO-2017/25/B/ST5/00971]
A novel and efficient method for synthesizing N-6-hydantoin-modified adenosines has been developed. The method utilizes readily available adenosine derivatives and involves a series of reactions to obtain the desired products.
A novel and efficient way for the synthesis of N-6-hydantoin-modified adenosines, which utilizes readily available N-6-(N-Boc-alpha-aminoacyl)-adenosine derivatives, was developed. The procedure is based on the epimerization-free, Tf2O-mediated conversion of the Boc group into an isocyanate moiety, followed by intramolecular cyclization. Using this method two recently discovered hydantoin modified tRNA adenosines, that is, cyclic N-6-threonylcarbamoyl-adenosine (ct(6)A) and 2-methylthio-N-6-threonylcarbamoyladenosine (ms(2)ct(6)A) were prepared in good yields.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据