期刊
CHEMBIOCHEM
卷 23, 期 2, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.202100631
关键词
biosurfactants; giant vesicles; mannosylerythritol lipids; recovery effect on damaged skin cells; self-assembly
资金
- JSPS KAKENHI [JP19H02724]
- JST CREST [JPMJCR20R3]
This study investigated the self-assembling properties and structure-activity relationship of chemically synthesized MELs, as well as their recovery effects on damaged skin cells. It was found that the synthetic MELs formed droplets or giant vesicles and the length of the fatty acid chains significantly affected their recovery effects.
Mannosylerythritol lipids (MELs), which are one of the representative sugar-based biosurfactants (BSs) produced by microorganisms, have attracted much attention in various fields in the sustainable development goals (SDGs) era. However, they are inseparable mixtures with respect to the chain length of the fatty acids. In this study, self-assembling properties and structure-activity relationship (SAR) studies of recovery effects on damaged skin cells using chemically synthesized MELs were investigated. It was revealed, for the first time, that synthetic and homogeneous MELs exhibited significant self-assembling properties to form droplets or giant vesicles. In addition, a small difference in the length of the fatty acid chains of the MELs significantly affected their recovery effects on the damaged skin cells. MELs with medium or longer length alkyl chains exhibited much higher recovery effects than that of C18-ceramide NP.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据