4.4 Article

Improving Structural Stability and Anticoagulant Activity of a Thrombin Binding Aptamer by Aromatic Modifications

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Pharmacology & Pharmacy

G-quadruplex-based aptamers targeting human thrombin: Discovery, chemical modifications and antithrombotic effects

Claudia Riccardi et al.

Summary: Research on DNA aptamers targeting thrombin began in 1992, with TBA being the most well-characterized aptamer. However, unmodified aptamers exhibit limited pharmacokinetic properties, leading to the exploration of chemical modifications to improve their biological performance.

PHARMACOLOGY & THERAPEUTICS (2021)

Article Biochemistry & Molecular Biology

Charge-Transfer Interactions Stabilize G-Quadruplex-Forming Thrombin Binding Aptamers and Can Improve Their Anticoagulant Activity

Kevan Perez de Carvasal et al.

Summary: Structural modifications at both ends of TBAs can enhance aptamer properties, pre-organize and stabilize the G4 structure, while maintaining sufficient flexibility for optimal thrombin recognition.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biochemistry & Molecular Biology

Beyond G-Quadruplexes-The Effect of Junction with Additional Structural Motifs on Aptamers Properties

Weronika Kotkowiak et al.

Summary: G-quadruplexes play a crucial role in nucleic acid structures and can be utilized as regulatory elements in cells. Extending quadruplexes with additional structural elements enhances stability and biological activity, and the specific interaction of G-quadruplexes with target molecules is pivotal. Future applications of G-quadruplex junctions hold promise, and there is still room for development in emerging research areas.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

Stability Is Not Everything: The Case of the Cyclisation of a Thrombin-Binding Aptamer

Claudia Riccardi et al.

CHEMBIOCHEM (2019)

Article Chemistry, Medicinal

Improved RE31 Analogues Containing Modified Nucleic Acid Monomers: Thermodynamic, Structural, and Biological Effects

Weronika Kotkowiak et al.

JOURNAL OF MEDICINAL CHEMISTRY (2019)

Article Medicine, Research & Experimental

Thermodynamic, Anticoagulant, and Antiproliferative Properties of Thrombin Binding Aptamer Containing Novel UNA Derivative

Weronika Kotkowiak et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2018)

Article Nanoscience & Nanotechnology

Fluorescent Thrombin Binding Aptamer-Tagged Nanoparticles for an Efficient and Reversible Control of Thrombin Activity

Claudia Riccardi et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

Article Biochemistry & Molecular Biology

Different duplex/quadruplex junctions determine the properties of anti-thrombin aptamers with mixed folding

Irene Russo Krauss et al.

NUCLEIC ACIDS RESEARCH (2016)

Article Biochemistry & Molecular Biology

Sequence-specific recognition of DNA minor groove by an NIR-fluorescence switch-on probe and its potential applications

Nagarjun Narayanaswamy et al.

NUCLEIC ACIDS RESEARCH (2015)

Article Multidisciplinary Sciences

A Universal Base in a Specific Role: Tuning up a Thrombin Aptamer with 5-Nitroindole

Vladimir B. Tsvetkov et al.

SCIENTIFIC REPORTS (2015)

Review Chemistry, Analytical

Aptamer binding assays for proteins: The thrombin example-A review

Bin Deng et al.

ANALYTICA CHIMICA ACTA (2014)

Article Optics

Formation and control of excimer of a coumarin derivative in Langmuir-Blodgett films

Santanu Chakraborty et al.

JOURNAL OF LUMINESCENCE (2014)

Article Multidisciplinary Sciences

Evaluation of Antithrombotic Activity of Thrombin DNA Aptamers by a Murine Thrombosis Model

Elena Zavyalova et al.

PLOS ONE (2014)

Article Biochemical Research Methods

Detection of thrombin using an excimer aptamer switch labeled with dual pyrene molecules

Qiang Zhao et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2013)

Article Chemistry, Medicinal

Synthesis, characterization and in vitro activity of thrombin-binding DNA aptamers with triazole internucleotide linkages

Anna M. Varizhuk et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)

Review Chemistry, Multidisciplinary

Structural, Electronic, and Optical Properties of Metallo Base Pairs in Duplex DNA: A Theoretical Insight

Pralok K. Samanta et al.

CHEMISTRY-AN ASIAN JOURNAL (2012)

Article Biochemistry & Molecular Biology

The circular dichroism and differential scanning calorimetry study of the properties of DNA aptamer dimers

Slavomira Ponikova et al.

BIOPHYSICAL CHEMISTRY (2011)

Article Medicine, Research & Experimental

Characteristics of a New DNA Aptamer, Direct Inhibitor of Thrombin

A. V. Mazurov et al.

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2011)

Editorial Material Hematology

Inhibitors of coagulation

S. Rangarajan

HAEMOPHILIA (2011)

Article Chemistry, Physical

Developing a computational model that accurately reproduces the structural features of a dinucleoside monophosphate unit within B-DNA

Cassandra D. M. Churchill et al.

PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2011)

Article Biochemistry & Molecular Biology

Thrombin-aptamer recognition: a revealed ambiguity

Irene Russo Krauss et al.

NUCLEIC ACIDS RESEARCH (2011)

Article Chemistry, Multidisciplinary

Programing the formation of DNA and PNA quadruplexes by pi-pi-stacking interactions

Sourav Saha et al.

CHEMICAL COMMUNICATIONS (2010)

Review Pathology

The future of aptamers in medicine

Makobetsa Khati

JOURNAL OF CLINICAL PATHOLOGY (2010)

Article Chemistry, Multidisciplinary

Self-Assembly of a Four-Helix Bundle on a DNA Quadruplex

Brooke A. Rosenzweig et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)

Article Chemistry, Multidisciplinary

Protein Recognition by an Ensemble of Fluorescent DNA G-Quadruplexes

David Margulies et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)

Article Chemistry, Multidisciplinary

Inhibition of Chymotrypsin by a Self-Assembled DNA Quadruplex Functionalized with Cyclic Peptide Binding Fragments

Jianfeng Cai et al.

CHEMISTRY-A EUROPEAN JOURNAL (2009)

Article Chemistry, Multidisciplinary

Digital Analysis of Protein Properties by an Ensemble of DNA Quadruplexes

David Margulies et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)

Review Chemistry, Multidisciplinary

High Fidelity Base Pairing at the 3′-Terminus

Amritraj Patra et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)

Article Chemistry, Multidisciplinary

Perylene bisimide dimers as fluorescent Glue for DNA and for base-mismatch detection

Daniela Baumstark et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2008)

Review Chemistry, Medicinal

G-quadruplexes: Targets in anticancer drug design

Tian-miao Ou et al.

CHEMMEDCHEM (2008)

Article Chemistry, Physical

Adsorption of naphthalene and quinoline on Pt, Pd and Rh: A DFT study

Gianluca Santarossa et al.

CHEMPHYSCHEM (2008)

Article Chemistry, Physical

Chiral recognition on catalytic surfaces: Theoretical insight in a biomimetic heterogeneous catalytic system

Angelo Vargas et al.

JOURNAL OF PHYSICAL CHEMISTRY C (2008)

Article Chemistry, Analytical

Aptamer-based biosensors

Shiping Song et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2008)

Article Biochemical Research Methods

Circular dichroism of quadruplex DNAs: Applications to structure, cation effects and ligand binding

Sattanathan Paramasivan et al.

METHODS (2007)

Article Biochemical Research Methods

Pyrene excimer fluorescence as a probe for parallel G-quadruplex formation

Huihe Zhu et al.

BIOCONJUGATE CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Tri-, tetra- and heptacyclic perylene analogues as new potential antineoplastic agents based on DNA telomerase inhibition

Claudia Sissi et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Synthesis of a non-cationic, water-soluble perylenetetracarboxylic diimide and its interactions with G-quadruplex-forming DNA

Ramakrishna Samudrala et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2007)

Article Chemistry, Multidisciplinary

Protein recognition and denaturation by self-assembling fragments on a DNA quadruplex scaffold

Debarati M. Tagore et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2007)

Article Chemistry, Multidisciplinary

Allosteric control of self-assembly: Modulating the formation of guanine quadruplexes through orthogonal aromatic interactions

Janarthanan Jayawickramarajah et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2007)

Article Chemistry, Multidisciplinary

Semiempirical GGA-type density functional constructed with a long-range dispersion correction

Stefan Grimme

JOURNAL OF COMPUTATIONAL CHEMISTRY (2006)

Review Biochemistry & Molecular Biology

Direct thrombin inhibitors - a survey of recent developments

A. Schwienhorst

CELLULAR AND MOLECULAR LIFE SCIENCES (2006)

Article Chemistry, Multidisciplinary

Tetraarylporphyrin as a selective molecular cap for non-Watson-Crick guanine-adenine base-pair sequences

Milan Balaz et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2006)

Article Computer Science, Interdisciplinary Applications

QUICKSTEP: Fast and accurate density functional calculations using a mixed Gaussian and plane waves approach

J VandeVondele et al.

COMPUTER PHYSICS COMMUNICATIONS (2005)

Article Chemistry, Multidisciplinary

A pyrene-labeled G-quadruplex oligonucleotide as a fluorescent probe for potassium ion detection in biological applications

S Nagatoishi et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2005)

Article Chemistry, Multidisciplinary

5′-Tethered stilbene derivatives as fidelity- and affinity-enhancing modulators of DNA duplex stability

Z Dogan et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)

Review Chemistry, Multidisciplinary

Interactions with aromatic rings in chemical and biological recognition

EA Meyer et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2003)

Review Biochemistry & Molecular Biology

Aromatic interactions in model systems

ML Waters

CURRENT OPINION IN CHEMICAL BIOLOGY (2002)

Review Chemistry, Organic

Aromatic interactions

CA Hunter et al.

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 (2001)

Article Chemistry, Multidisciplinary

Naphthalene- and perylene-based linkers for the stabilization of hairpin triplexes

S Bevers et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2000)