期刊
CEREBRAL CORTEX
卷 32, 期 12, 页码 2644-2656出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhab371
关键词
cognitive impairment; fMRI; gamma oscillations; rTMS; TMS-EEG
资金
- National Key RD Program [2018YFC1314500, 2018YFC1314504]
- National Natural Science Foundation of China [62176044, 81701297, 81801124, 82071483]
- Sichuan Science and Technology Program [2021YJ0186]
This study revealed that applying 40-Hz high-frequency rTMS over the bilateral angular gyrus in patients with probable Alzheimer's disease significantly improved cognitive function by modulating gamma-band oscillations and enhancing various connectivity within the brain.
Dementia causes a substantial global economic burden, but effective treatment is lacking. Recently, studies have revealed that gamma-band waves of electrical brain activity, particularly 40 Hz oscillations, are closely associated with high-order cognitive functions and can activate microglia to clear amyloid-beta deposition. Here, we found that compared with sham stimulation, applying 40-Hz high-frequency repetitive transcranial magnetic stimulation (rTMS) over the bilateral angular gyrus in patients with probable Alzheimer's disease (AD; n = 37) resulted in up to 8 weeks of significantly improved cognitive function. Power spectral density analysis of the resting-state electroencephalography (EEG) demonstrated that 40-Hz rTMS modulated gamma-band oscillations in the left posterior temporoparietal region. Further testing with magnetic resonance imaging and TMS-EEG revealed the following: 40-Hz rTMS 1) prevented gray matter volume loss, 2) enhanced local functional integration within bilateral angular gyrus, as well as global functional integration in bilateral angular gyrus and the left middle frontal gyrus, 3) strengthened information flow from the left posterior temporoparietal region to the frontal areas and strengthened the dynamic connectivity between anterior and posterior brain regions. These findings demonstrate that modulating gamma-band oscillations effectively improves cognitive function in patients with probable AD by promoting local, long-range, and dynamic connectivity within the brain.
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