4.6 Article

Volume Reduction of the Dorsal Lateral Prefrontal Cortex Prior to the Onset of Frank Psychosis in Individuals with an At-Risk Mental State

期刊

CEREBRAL CORTEX
卷 32, 期 10, 页码 2245-2253

出版社

OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhab353

关键词

at-risk mental state; dorsal lateral prefrontal cortex; magnetic resonance imaging; psychosis; schizophrenia

资金

  1. Japanese Society for the Promotion of Science (Kiban C) [18K07549, 18K15509, 19H03579, 18K07550, 20H03598]
  2. Japan Agency for Medical Research and Development (AMED) [JP19dk0307029]
  3. National Institutes of Health [P41-EB015909]
  4. Grants-in-Aid for Scientific Research [20H03598, 19H03579, 18K15509, 18K07550, 18K07549] Funding Source: KAKEN

向作者/读者索取更多资源

This study found that reduced gray matter volume in the right dorsal lateral prefrontal cortex (DLPFC) may be a potential marker for future onset of psychosis in individuals with at-risk mental states (ARMS).
Although some individuals with at-risk mental states (ARMS) develop overt psychosis, surrogate markers which can reliably predict a future onset of psychosis are not well established. The dorsal lateral prefrontal cortex (DLPFC) is thought to be involved in psychotic disorders such as schizophrenia. In this study, 73 ARMS patients and 74 healthy controls underwent 1.5-T 3D magnetic resonance imaging scans at three sites. Using labeled cortical distance mapping, cortical thickness, gray matter (GM) volume, and surface area of DLPFC were estimated. These measures were compared across the diagnostic groups. We also evaluated cognitive function among 36 ARMS subjects to clarify the relationships between the DLPFC morphology and cognitive performance. The GM volume of the right DLPFC was significantly reduced in ARMS subjects who later developed frank psychosis (ARMS-P) relative to those who did not (P = 0.042). There was a positive relationship between the right DLPFC volume and the duration prior to the onset of frank psychosis in ARMS-P subjects (r = 0.58, P = 0.018). Our data may suggest that GM reduction of the DLPFC might be a potential marker of future onset of psychosis in individuals with ARMS.

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